GLP-1s fixing knees?!

I agree with what HeartCake is saying. It seems like weight loss is only ONE piece of the puzzle. I saw a chart that listed all the existing and potential anti-obesity medications... it's wild how many different targets they're exploring!

It's interesting how this is playing out in society. I saw a post on Reddit that said, "all the mean skinny women better watch out, cause the women who had to develop a personality are suddenly going to be hot" LOL!

Heal-Fam said:

The important question that this raises is whether stopping glp1s leads to a loss of the benefits that are independent of weight loss.

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That's something I've wondered about too. I'm planning on staying on a low dose indefinitely to keep those benefits!

Fair point tho — we avoid sketchy suppliers but then turn around and buy from Amazon lol. The needle sterilization marks are a real question too. Best defense is just sticking with sellers you actually trust.

the idea of trying it before total knee replacement makes sense if there's time to evaluate - the anti-inflammatory effects that show up in the cartilage research are the mechanism worth watching, and any delay in a major surgery that ends up not being needed is worth the trial. the timing question is whether the knee situation allows the window to try something first

Will look into that, appreciate having a specific name to research! There's been ongoing inflammation trouble the past couple years, hot, sore knees and such, but never the hip before, so this had been a bit worrying.

Appreciate that. Considering trying this drug class mainly for the anti-inflammatory benefits, weight loss would be a nice side effect but isn't the main draw. I have rheumatoid arthritis. Curious whether your knee improvement came purely from the weight dropping, or did it already feel better before you'd lost much?

Also, genuinely thrilled for you on the pain relief. Living in a two-story house myself, I know exactly how brutal stairs get with leg pain.

Would losing 100 lbs improve how your knees feel? It could help a little, but I doubt it beats what GLPs do. My knee issues showed up when I weighed quite a bit less and trained way more, that's my genetic lottery. Sema has nearly wiped out that pain, though there's still plenty left to lose. Did anyone design them for pain relief? Depends how you look at it. A trial targeting both weight loss and knee arthritis is underway with Reta. They started out to manage blood sugar first and later work moved toward obesity, and the anti-inflammatory effects help quite a bit. One survey said 1 in 8 Americans are taking a GLP-1 currently, though I'm not sure how accurate that figure is. Either way plenty of people use them, whether through prescriptions or other channels.