Reta fatigue: Does it ever lift?

1mg to 2mg quickly, good movement at 3mg, then stalling at 5mg with the fatigue staying is a common ceiling pattern on reta. the fatigue question in the OP might track differently when stacked with tirz versus solo - the interaction changes how both feel. what did you end up doing at the stall point?

Started running Tirz for maintenance following a big weight loss, mostly to keep food chatter quiet. 4.5mg did the job there, but even once the early fatigue wore off, my energy still felt somewhat reduced compared to my baseline. That continued after a couple months at that same level. Pulled the dose back to 3.5mg and added in a milligram of Reta, and now everything seems to click. Get the full upside of 4.5mg Tirz without energy taking a hit.