Personally I've noticed this medication (technically the higher-dose weight-loss version, same drug though) has cut way back on my drinking. Pretty much strictly a vacation drinker these days, could easily stretch six months or more before touching a drop again. When I do have one though, no noticeable difference. Admittedly a lightweight given how rarely I drink, but beyond that never dealt with nausea or stomach trouble from it. Same as a good chunk of what gets reported here as side effects, honestly seems to trace back mostly to hydration levels. Stay hydrated and you're generally fine. Just don't skip water and then go overboard drinking.