A few thoughts on Reta. It's a peptide, so everything hinges on signaling, and I've heard inflammation and gut problems may dull that signaling. Even with inflammation and gut trouble I still responded well once I landed on the right dose. I titrated aggressively, starting at 2mg and settling at 4mg in under a month. Certain folks respond intensely and need very little, others need a bit more. My wife responds intensely: at 1mg it was nearly too much for her, and the worst side effects settled over several weeks. About two months in she got raised to 1.5mg and continues dropping a pound weekly. My guess is the dose where you notice anything is about 3 to 4mg. If side effects worry you, there's no need to hurry the effect, and raise the dose by .5mg weekly or every two weeks.