Anhedonia on Tirz - anyone else?

Anhedonia tends to show up a lot more at the higher end, like 10mg plus. Just stick with the standard dose and gauge your own response.

Being pretty vulnerable here, but honestly the biggest win for me isn't even the weight loss, it's losing that constant chase for quick dopamine hits. Realized my whole day used to revolve around chasing those hits through a dozen different outlets, and resetting that response was genuinely necessary. Just hoping I don't end up somewhere down the line feeling that same empty pull, minus the dopamine to numb it.

I think you're onto something with that reward-chemistry angle. The mind finds its outlet no matter what. When I gave up drinking, sugar stepped in as the substitute. Once I started the third compound, my sugar cravings got wiped out almost immediately at first. But eventually that same underlying pull just found a new target and started wanting literally anything??

So now apparently that little hit lands whenever the next mystery package shows up at my door. And, well, the chest freezer downstairs is basically full at this point.

Going to look further into this, haven't come across it with other peptides either. I do struggle with a flattened mood on the dual-action medication, and nothing I've tried has genuinely countered it for me. Getting myself moving is the hard part, but once I'm actually doing something, I generally start feeling better about it. Lost interest in a lot of things that used to genuinely make me happy. Hoping now that I'm at goal weight and cutting back the dose, things will start improving.

Same here, I had to leave high dose Tirz and I'm on Reta 4 mg now because of the anhedonia. Felt low, zero drive. About 3 weeks later I had more energy and my mood came back. Your dose is pretty high, so try lowering it a bit. I'm still using Cagri and waiting on Elora. I want to lose maybe 5-10 more lbs, these last months I had NO motivation at all.

A couple of months back I stacked reta on my tirz and my anhedonia became severe. Once I dropped reta, it disappeared. Reta is adored by many, but not by me. Plain tirz works for me.

I was happy on Tirz at 2.25, but loss eventually slowed to nothing. Reports of tiredness and joylessness on higher tirz doses kept coming up in what I read, and noticed a few people stacking Reta looked far happier, therefore I tried that instead of climbing the tirz dose. I began very low, .5, and increased slowly. Its only downside: occasional creepy-crawly or tender patches of skin, which passed. For weight loss it delivered nicely, while tirz holds the food noise down.

Adding reta on top of tirz brought on serious anhedonia for me. Just three 1 mg doses, yet the effect was obvious and awful. Dropping reta and going to twice-weekly tirz made everything way better. Bloodwork on testosterone is probably wise once you hop aboard.

Stopping reta fixed my anhedonia, it was the culprit. Roughly two weeks after my final reta shot I felt normal again. Tirz never affects me like that.

that's interesting, might be onto something. for me it's night and day, cycled through mounjaro repeatedly over 15 months. every time, it takes about a day before the anhedonia sets in. the moment i stop, it lifts and i enjoy things again. it's not that joy vanishes, more that videogames, tv, stuff i used to love just don't land. i get listless and nothing pulls me in. not clinical depression, i feel okay otherwise, just nothing feels fun. for people who get this, it's tied to the mounjaro itself. my case hits hard enough that there's zero ambiguity. someone with mild or zero anhedonia might question whether it's the drug, but given how severely i get it, i have no doubts. still better than staying overweight, though not sure it's worth going permanently joyless if it hits this hard.