Weight Comes Back After Stopping GLP-1s?

Not personally, but there are friends and coworkers who've come off and are holding steady. Really varies person to person. Hormonal or metabolic issues make it a lot tougher, though not impossible. Even without those factors, if the original weight came from lifestyle habits or food noise, maintaining afterward can still be a real struggle. Regardless of what actually drove the loss, GLP or otherwise, the body seems wired to defend a higher set point and lean toward regaining.

From what's been seen across various forums and among people known personally, there's usually a rough patch where hunger comes roaring back before eventually settling closer to pre-medication levels. For some, though, that baseline hunger was already rough enough that going back isn't appealing.

Three months off at this point means it should be fully cleared from the system. A small bump on the scale after stopping isn't unusual, since these drugs do a lot for inflammation too. No plans to stop currently, but if it happened, a quick 6lb jump seems likely, matching what happened in reverse at the start.

Most people end up needing more than their old dose just to start losing again. And yeah, most who stop regain the bulk of it back within a year.

Sadly, after a break and restart, most people see slower loss and weaker effects. That doesn't mean it fails, just be more patient, climb back to 15 mg, and count on a slower pace. Still very possible, wishing you the best.

Thanks for voicing what people rarely admit, and so well. Long before Mounjaro or GLP-1s, studies showed that almost everyone who lost substantial weight regained it when tracked for 3-5 years. Anyone who loses a lot on one of these drugs and then quits has simply joined that well-studied, well-known crowd who nearly all regain. Lose a lot on Mounjaro, then stop? The odds of regaining at the 3-5 year mark approach 100%. Just look at the stories people post here daily about life before Mounjaro, how they lost and it always came back. Realistically that is what happens to them too if they stop. You fight a million years of biology, as you said, and most of us lose.

my issue with a bunch of the conclusions pulled from this kind of data is that it's all built around the 'average' person, or lab animal. i think a lot, maybe most, people would gain back real fat if they came off their glp-1 for several months, especially those who could never lose weight successfully without the medication in the first place. but there's another group, people who'd already beaten their food struggles before and just use glp-1s to make the process easier, and i'd count myself there. people like that would genuinely love more data on tolerance over time. though to be fair most of us in that second camp also haven't pushed our doses very high either, so maybe it's not even the right question to ask, but i'm still curious.

Not everyone wants to hear this, but a large share of folks using GLP1 meds to lose weight, maybe 80-90 percent, never really change their eating habits, they just lean on the injection to manage portions. Fine for them, but it does nothing for how they actually handle food or calories long term. Same junk, smaller amounts, so stopping the drug sends them right back to old patterns. Compare that to folks who put in effort learning to count calories and understand what they eat, they tend to hold their results even off the medication. Some conditions truly make this impossible, I won't deny that, but I think that group gets exaggerated, when really most people just won't change anything beyond their injection routine.