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Switched in October after two years of sema on and off. Love it. Doing that compound with B6 additive which supposedly helps with side effects. Not sure if it's the B6 or the tirz, but zero bad side effects since starting. Sema felt like 'maybe this is working?' Tirz feels like 'I want to feel...

intranasal has higher bioavailability, skips the liver so it works faster and you need less. also hits your brain more directly. effects should be quicker. and yeah subq not im, almost nobody does im.

chest pressure is def a thing, happens to me too. usually goes away pretty quick, like 5-10 min tops. if it bugs you, just drop the dose a bit and see if that helps. mine doesn't really need burping or anything, it just passes on its own.

Yeah, totally agree, Gym_Taco. It's not a free pass to eat whatever you want. It's a tool, but you gotta use it right. It's frustrating that the mental aspect is so strong! I guess it takes time for the brain to catch up with the body.

I looked into Cagri and Sema too. Sema is cheap. But there's something to be said for simplicity. Reta might replace Tirz when it's approved. Medicine takes so long to get approved. By the time Reta is out, people will have moved on. It's nothing new.

Happy to share what might help someone!

I was gonna DM, but this might help others, maybe? I've been on Phenofibrate forever (cholesterol med). Recently, studies showed it has side effects like 'over-emotional.' We cry at stupid things, and I used to wonder why. This might be fighting the effects of another chemical. I won't know...

If your cravings are emotional, these peptides might not help. I think there's some talk, maybe proof, that some affect dopamine and can impact emotional eating. But I hear a lot of people with BED or other eating issues don't get the "I don't want food" effect that people who are always hungry...

This is wild. I'm around 2000 calories, maybe less. I am losing weight, but wow, it's hard. To be hungry, but afraid to eat (much). My work keeps me pretty busy. But in winter, it's like 5 hours instead of the whole day. This ain't lifting weights, it's hard labor outside. Oh yeah, my labs are...

I thought about stacking with Reta, but I probably didn't go high enough on it. I'm also considering Tesamorelin. 😊 Thanks!

I started with Mounjaro pens. They come with a sheet that shows the full titration schedule. So I followed their standard for increasing the dose.

So, I started on Tirz a while back, and at first, it really helped curb my cravings. But now it's like my mind is fighting back. I know I can't go wild eating whatever I want. The results would be awful! It's just, I've struggled with my weight my whole life, and it's like those old cravings...

Replying to a question above I see an obesity medicine specialist! They are double boarded in other areas (endocrinology, for example) so they are well versed in all the things that are going on. I hope that helps! Good luck with your appointment!

Oops! Almost forgot: About 5'7", 43 years old. Size 22 to a size 6. Size 2x to a size small. So many non-scale victories!

Okay, buckle up, novel incoming! So, here I am. Officially in maintenance. Never thought I'd see the day. HW: almost 300 lbs, Lowest Weight Before Meds: ~290 lbs, Current Weight: a bit over 140 lbs Started on Mounjaro in late Nov '22. When the anniversary rolled around, I figured the weight...