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Week two at 4mg is usually the beginning of the suppression window, not the peak of it - most people notice the effect becoming consistent between weeks 3 and 6 as the receptor saturation builds.

Working with the lyophilized form directly is unnecessary for any standard protocol - reconstitute in the original vial, then transfer to storage vials if you're splitting doses.

226 to 161 at 5'3 is a real result. GI sensitivity shifts on long-term use are worth watching.

That's exactly why I'm using a compounding pharmacy even though it's out of pocket. My insurance is likely to stop covering it at some point.

My regular doctor wrote the script but the insurance won't cover, so I get it from a compounding pharmacy.

I used an online provider. It's convenient because their doctors prescribe it, but it's pricey, like $400 each month. I'm seeking a more affordable compounding facility.

I'm with Well-Babe on this one. The mental load and anxiety are way down since starting GLP-1s. If I can stay on it forever, I will.

The world's constantly bombarding us with messages to EAT and CONSUME! I feel like Ozempic's the only thing fighting back. They use every trick to make us eat/drink junk; it's not weird to try to defend against that. If they're jealous, it's because they're fighting it too and think you're...

I don't broadcast that I'm on Ozempic. People are too quick to judge. My health choices aren't up for discussion.

Yup, I'm 6'3". That helps spread it out!

Thanks everyone! And, D-K-W-99 - awesome progress on your journey too!

Hit a milestone. 15 months in. Started at 348 lbs, now at 246, aiming for 160. Dealing with some loose skin, but honestly, feeling this good makes it worth it. Highly recommend taking progress pics – helps when you're battling body image issues.

Update: Seeing the cardiologist tomorrow. Will advise. Thanks again for the input everyone!

I agree with MedSet762. Some people feel it right away, but for me, it took a few weeks and a dose increase before I really noticed a difference.

Thanks Riley03, I appreciate that advice! I will seek immediate medical advice.

Hey everyone, hoping someone can chime in with some advice. I transitioned from a different GLP-1 to Reta, slowly increasing the dose. I started noticing effects around 13 units, but still had some food cravings. I've since added another med at 20 units over about a month and a half, and the...

I totally get that! It's wild. Like, I have snacks in the house that I literally forget exist. Used to be, I'd be lying in bed at night obsessing about potato chips. Now? Nothing. I even bought a cake a couple weeks ago, ate a sliver every day or so, and then just...threw the rest away. Insane!

This is really a conversation to have with your doctor and maybe a nutritionist.

I've heard some people say you can't build muscle on these meds, but I'm calling BS. I've seen it happen firsthand. Keep crushing it!

Smoking hot in both photos! Congrats on your progress and good luck building muscle 💪