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Bottom line: mounjaro doesn't make you gain or lose, it changes your appetite. So I'd stay with the smaller dose while tracking calories to stay within maintenance. Take me: I'd gladly eat more, my dose isn't so high that I've lost all desire to eat, just enough that I never feel starving. I...

Would love to hear others' experiences too! I take 3mg reta weekly split into 2 doses, and thinking for my next increase to hold reta at 3mg and add 2.5mg tirz for extra appetite suppression :)

Hi OP! Been on a couple of months, .25 for 5 doses then .50. Weeks 1-2 were bumpy, week 3 much better, so I figured I'd adapted and would step up to .5 following week four. Week four was awful though, way more nausea and tiredness, so I held .25 through week five and that went much better. So...

I had no period for 2 1/2 years and figured I had early menopause (I'm 45). After 7 months on Mounjaro and 70+ lbs lost, give or take daily, my periods came back 2 months ago, and this month's was very heavy. Being overweight affects the cycle so I assumed it was the weight loss, but now I...

Good luck! Metformin and Gliclazide were my T2 meds and my HbA1c always sat at 8-11%. My doctor switched me to Ozempic last September. Over 8 months my body weight dropped by a third (277 to 187lbs) and both diabetes meds were gone. Now it's just 1mg weekly and nothing else, HbA1c 4-5%, feeling...

Also just noticed the label warns against use past a certain window from first opening, and I honestly don't know whether that window already started since a needle was missing. Been sitting in my fridge over three months now, so figuring the strength has probably dropped somewhat from normal.

Wow, just wow!!!! Such an incredible thing you've achieved, congratulations, and on top of that you're managing your health so much better too. It's amazing. I'm honestly blown away reading everyone's stories here and how much success they've had using this medication for different reasons...

Went ahead and added another milliliter of diluent, let it come up to room temperature, and it's looking fine now. Come morning, if it pulls up smooth and glides right into my fine-gauge syringe with no resistance, I'll go ahead and use it, otherwise it's straight in the trash. Sound...

Hey, yeah, the doctors used the term 'rapid weight loss,' and I've had bloodwork done too. Just seemed strange that this all kicked off now after a full year on the medication. So I've been on birth control for years and years, but apparently this drug class can weaken it or make it stop...

Stopped caring for colas and anything carbonated almost overnight. Had already moved to diet and sparkling water years back and genuinely enjoyed both. These days maybe one soda every seven days, and not even all at once.

Would recommend studying up on the terminology involved and really nailing down the difference between milligrams, milliliters, and units, since even with explanations already provided, dosing mistakes still seem like a real risk.

Same thing here. This is round two on sema since I regained everything plus more after stopping the first time. Given how much it helps with my PCOS specifically, I think this is a lifelong medication for me at this point. Once I hit my target weight though, I'm planning to taper down to the...

Lost 40 pounds over six months on mounjaro. Gained about 5 pounds over six months on ozempic.

Running reta, tesa, ipa and cyp at 56 with 12 lbs gained in 6-8 weeks is the recomposition picture a lot of people are going for when they stack that way. The muscle side outpacing the fat loss in the first couple months at low doses is exactly what the early phase tends to look like. How's...

The recommended titration schedule exists specifically to prevent the rebound fear you're describing - each step down needs enough time at the lower level for the system to stabilize before reducing further. The anxiety at step-down is common; the schedule is the answer to it.

Sharps disposal is worth setting up properly once the volume starts building - most pharmacies will take sealed sharps containers for free, and many states have mail-back programs for pharmaceutical waste. The household trash route with a sealed container works in a pinch but the pharmacy...

Twins after a long fertility journey and now on Mounjaro doing great is a lot of things working out simultaneously. Congratulations on both counts.

The Metformin plus GLP-1 experiment in non-T2D users consistently shows minimal additive effect on weight - the insulin sensitization benefit exists but the magnitude is small and unlikely to register against GLP-1's own effects. The evidence base for Metformin as a weight loss add-on in...

The persistent hunger at high combined GLP-1 doses is worth investigating at the receptor level rather than just adding more - tolerance is possible at that volume, but the more likely explanation is that something else is driving the hunger that isn't GLP-1 mediated. Worth reviewing protein...

The basic panel recommendation is the right starting point before adding more specialized markers - FBE, metabolic panel, and hs-CRP gives you the inflammation and organ function baseline that everything else layers on top of. The comprehensive list gets expensive fast; knowing what you're...