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ha, this tab has been sitting open for a whole day while I waited for somebody to teach me something! Nobody here is on maintenance? Surmount-Maintain phase 3 had people stay on their top tolerated dose and they held their goal weight with no regain. The ones who stepped down to 5mg kept about...

Day one and two were like that for me too on 0.25 Ozempic. Now that I'm nearly two weeks along, it's gone. Some days I can force down maybe 1200-1400 cals, other days I'm hungrier, depends on how close the next shot is, how active I was, what I ate the day before. But those first two no-appetite...

Weigh every single benefit of this drug class against the merely possible downsides, and it's honestly not a close comparison. On top of everything else, it helped me quit smoking entirely, drinking barely crosses my mind these days (not that I was ever heavy into it), and my bloodwork has...

SW 220, CW 162 Got started back in April 2025. No exact target number in mind, but probably not too far off now. Standing at 5'9", so maybe another fifteen pounds and that should about do it.

Or swing the other way entirely and go starch-heavy instead. Either way, reta's my favorite. Best performer for weight loss even looking at two-year data. Tirz paired with elora might eventually beat it out in trials, but who knows. Personally I'd ease into reta as a standalone treatment over...

Genuinely can't wrap my head around why people default to once weekly dosing. Half-life sits around six days. That whole receptor desensitization concern is overblown in my view. Splitting the dose has worked really well for me personally.

You've done incredibly well, genuinely happy things are feeling better for you. PCOS is no small thing, and anyone who's never dealt with it has no idea how lucky they are.

The medication just won't let you enjoy it anymore. Used to drink eight to ten diet sodas a day. Now I don't even want a single one. Tastes disgusting honestly.

The 2 pre-drawn syringe approach for a Europe trip is exactly what a lot of people do. The question on 2.5 weeks is whether you dose weekly or can stretch to every 9-10 days at the same dose - the half-life gives you some flexibility. TSA-wise, keep everything in the original packaging with any...

On the liver question, others tracked reta and liver numbers if you want to compare.

401 and setting stepping goals of 350 then 300 is the right way to frame a big journey. The OP at 8 lbs from goal is what that long road looks like at the end. Maintenance is where the goal-setters and the goal-holders diverge - most people find a lower maintenance dose and stay there, it...

The non-diabetic weight loss use case was where the clinical benefit became impossible to ignore - the trial data was strong enough that it changed prescribing norms significantly. The broader cardiovascular and metabolic benefits beyond weight have continued to accumulate in the follow-up data.

Gray market tirz often runs overfill - concentration per stated mg can run 15-40% high, explaining the stronger effect at lower dose.

Bloodwork-confirmed reta sourcing data is thin in public posts - most people reporting results share peptide panel numbers rather than GLP receptor assays, so the verification is indirect. The community has seen mixed quality variance from the same suppliers over time.

No-response orders from overseas vendors break down at three points: payment processing, customs prep, or shipment. At a month without any communication, initiating a dispute through your payment method is the practical step.

Yeah, and what kind of food are you eating? A thousand calories of junk food is gonna have a way different effect than a thousand calories of healthy stuff.

message your doc and say you're barely eating—ask for a refill at 2.5 for another month. right now it's mechanical eating. even when you don't want it, even when it tastes off. calorie-dense stuff like shakes or peanut butter. not as nutritious but you gotta get it in any way you can.

Same here. But I know why. I think I'm eating small portions, but I'm still eating too much. And despite trying to eat 'lower carb', I still have too many carbs. It's the same for you. That's why we're not losing weight.

Really important to watch protein intake and hit the weights hard when you're on this.

lost over 50% body weight (started 286, now 140). tracked calories and walked the whole time. I have pcos but my insulin resistance is gone now. everyone's different but I knew from day one I was going all the way to a healthy range.