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The absence of side effects at 2.5mg isn't necessarily a sign it's not working - response varies significantly by individual, and some people feel only appetite change without the GI or sleep disruption. The clinical trial starting point for dose selection is a reasonable strategy; 2mg...

Clinical trials have pushed to much higher weekly doses than standard protocols use, so standard starting doses sit comfortably inside the safety envelope.

The GIP receptor added by Mounjaro is what drives most of the performance difference - semaglutide is GLP-1 only, so the dual agonism creates a meaningfully stronger combined effect, especially for people who plateaued on sema.

Mounjaro hit my food aversions in waves. Chicken and eggs went first — couldn't even smell them around weeks 3-5. Beef stayed away for about 4 months total. Dairy mostly held up except for milk in coffee. Fish and shellfish never bothered me at all. Whole thing slowly normalized but on a longer...

You're absolutely glowing!

You look amazing! Seriously, goals!

Thanks for the input, everyone! Sounds like most people stick to their official weigh-in day. I think I'll try to do that too to avoid getting too obsessed with the daily fluctuations.

Alright, quick update. Got down to around 333, but then a steroid shot for my back threw things off. Gained like 6 pounds in the following days, which was a bummer. Knew it was coming, but still. Anyway, my official weigh-in day is Tuesday. Last Tuesday I was at 335, so not too bad. Woke up...

Congrats! Keep up the great work!

Your posture looks way better too! You must feel amazing.

Thanks for the extra advice. I'll pass it on and she can discuss with her doctor.

Thanks for the info. Doesn't sound like fun.

I've heard of a few places that sell peps. There's one online that seems legit. Always do research before you purchase anything though. I can't vouch for them, but it's where I get mine. Be aware of the disclaimers about some peptides.

I'd tell her to begin with a very small amount, and increase it gradually. My wife experimented with it herself, using only 1 mg instead of the typical 1.75-2 mg dose. In less than 15 minutes, she was really flushed and reaching for the allergy pills. While that's a common side effect, it was so...

Wow, I was asking on behalf of my wife because she isn't a member here. She brought it up, and I was like, 'What's that?' and 'Have you researched it?' I'd never give her anything without her knowing. I was curious because I was worried about potential side effects. She got it herself. I wanted...

That's pretty accurate. I got a small boost from being on it for a year. I was taking 25mg twice a week, and it took 9 months for my numbers to come back down and for me to feel normal again. The bloating and higher estrogen made it not worth it.

Hey, everyone. My wife's getting older, and her sex drive isn't what it used to be. I've heard 1.0 mg of PT-141 might help. Will that work? Is nausea a common side effect? Should I start her with a lower dose, like 0.5 mg? Any help would be awesome.

Yep! It worked for me, I could grab it.

I saw a post about someone's A1c dropping from 13 to 8 in ONE MONTH on just a low dose of Ozempic! And they lost about 5 lbs too! Amazing how fast it can work for some people. My own decrease wasn't that quick, but it was still impressive.

Awesome, that's what I was hoping to hear! Especially that it's based on data from multiple studies. Thanks!