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For a colonoscopy your lower end has to be spotless, and GLPs slow your gut down, sometimes a lot, so pausing makes sense. I paused for 2 weeks before mine. Honestly, right as cravings crept back, the dreaded prep began, and I lost tons of weight during it. Straight afterward I devoured one...

Same here. I lost 10kg and went back to lifting after 10 years away from a gym. The scale stopped moving but the change is still happening. Your body fat percentage must have plummeted!

You might get very nauseous plus diarrhea, those are the two big things to watch for. Insurance forced my move from mounjaro to ozempic, and since I started at 2 mg, ozempic still wrecks my stomach, and I'm in week 6. Today is my week 6 dose day and I keep delaying it all day since I know what's...

Funny thing, I mixed up a 10mg SS31 vial and injected 1mg to see how it felt while considering a protocol with SS31, Mots, NAD and 5Ami, and 1mg gave a mild boost. Unsure what 5, 10, 20 or 50mg would do to me. Pleasant feels for a first try. Two weeks back I ran Mots the same way and 1mg gave...

You don't need to wait for the reconstituted peptide to reach room temp before using it. Venting the vial to equalize pressure just makes drawing your dose easier, since a vacuum inside makes extraction much harder. Official advice is 4 weeks max, but I'm fine with 2-3 months at slightly higher...

Totally reasonable thing to ask. Both vials and pen cartridges come sterile from online shops. For vials, check that the maker states the sterilization method (steam, radiation or similar) ahead of purchase, and if they can't give you that, skip them. I prefer pen cartridges since they're fairly...

A lot of people plateau on 2.0mg of Ozempic, then swap to Zepbound, which is stronger, and drop further.

Reta was the first thing I ever tried. Not that I'm heavy at all, yet I tried it at the very start of my peptide use and the weight dropped fast, faster than I expected and probably faster than healthy, even at a low dose. Lean turned into very lean. Another peptide with an instant, noticeable...

Insulin resistance, weak appetite suppression and metabolic issues can all play a part, but focusing on them may overcomplicate things. On paper weight loss is very simple, even if it's hard in practice. Your body needs a set number of calories, set mainly by how heavy you are and your make-up...

BringsSnacks Best explanation I can see is that the second vial was defective. Was that batch tested at all? Edit: after rereading, were the vial and BAC both chilled? Hmm, even so I doubt that explains what you're describing.

Maybe return to weekly for a bit and judge from there. If every 2 weeks suits you better, move up to 5mg, and 5mg might be due either way.

This puzzle fascinates me, since plenty of folks on here claim reta quiets hunger and food noise to a lesser degree than tirz, yet every study shows more weight loss. I doubt the gap in how much hunger is cut is truly that large. Suppose glucagon agonism adds 100kcal a day of burn over tirz...

Not sure what else to try. Started mounjaro back in October and dropped roughly fifty pounds quickly at first. Everything stalled around December, right after catching the flu threw my routine off, and my body's basically refused to budge since. Bouncing within a narrow range for months now...

The urge to smoke might just fade naturally on its own. On the chronic pain front, a handful of folks in my circle running oz or tirz say their inflammation and pain levels have dropped noticeably.

Genuinely none of their business whether someone's on this medication class. Part of a recovery program myself and still use cannabis. They're aware, but disclosure was never something forced on me.

Fantastic progress! Congrats on the transformation. Genuinely astonishing how many health issues this medication ends up resolving.

29 lbs down and feeling better even when no one has mentioned it yet is the internal version of the win that matters more long-term. 271 to 242 is a meaningful move and the social noticing usually lags by another 20-30 lbs. The OP's 110 lbs is where you can't not notice it, but the internal...

The trial data comparison on percentage loss is the right way to frame the Tirz vs Reta decision for someone still far from goal - when your target is 30% or more of starting weight, the evidence does favor Reta on average. Individual response still varies but the expected value argument is...

I'm figuring out tapering as I go too and yeah there's not much out there about it. Starting low and ramping up slow has worked fine, losing weight and feeling good so far. No side effects yet which is a relief.

On tirzepatide for life at this point. Rather take one shot a week than pile on blood pressure, cholesterol, and blood sugar pills every single day. My health's better now than it's been in years.