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SLU and bam15 got me reading the moment they appeared. Both are interesting, but I'd say nowhere close to ready for people, with just a handful of basic animal studies, which sound cool but are a very long way from safe for humans. Both are still under investigation, but I think focus will move...

I've done a month at 2 mg and the scale barely moved these last 2 weeks, maybe 3 lbs. I'm considering 3 mg but probably wont. I'll hold at 2 mg another month, then decide.

Through my first seven months, while I was actively dropping weight, I stuck strictly to a clean diet. Reached my target by month seven, down 62lb, 27% of my body. That was well over a year back now, April of 2025. Now I've been on the second compound for close to 23 months and eat whatever...

Currently at 12.5mg with zero side effects to report. Been stepping up roughly every four weeks without a hitch. If you're nervous about it, just pace your increases slowly.

Most people end up regaining if they stop taking it in some form (like we've all experienced repeatedly before). This isn't a willpower issue (we've clearly established that's not the actual root cause, so let's drop that framing). Treat it as an ongoing, long-term medication and plan accordingly

That's fantastic! New pants have become a necessity lately, and they're already starting to feel loose too. Love how clothes fit now, none of that constricting feeling anymore.

Mind feels noticeably sharper these days. Took a break from it recently, roughly two weeks, and really noticed the contrast once I did. Just my own anecdotal take on things here.

Wondering if your amount is just set too high? Daily nausea does sound miserable, sorry you're dealing with that. Had a ton of it myself early on and whenever I bumped up, but six straight weeks feels excessive. Also relate to certain foods, like yogurt or cookies, being totally fine some days...

Sudden unexplained weight loss really deserves medical attention. Make sure you tell your doctor about every symptom you're noticing. Don't assume that using the first compound briefly a couple years back has any bearing on what's happening now.

Took my last shot on July 2nd at 1.25, so fingers crossed the symptoms wind down soon. Some days I actually make it fine until evening without constant anxiety hanging over me, which gives me a bit of hope this might be gradually letting up.

Amazing work!! That's a huge milestone and it's clear you're doing everything right, keep it going!

Worth adding, the researchers behind SLU-PP-332 found it lacks oral bioavailability, so capsule form won't do much good there. A follow-up compound, SLU-PP-915, apparently does have that bioavailability for the same target, though nowhere obvious to actually get it yet. There's a study worth...

You've definitely been dropping weight, but is the food intake actually enough overall? I'm 46, female, 5'2, and average around 1500 calories a day myself.

Mine shipped from a pharmacy that turned out completely legitimate. Huge relief honestly, was pretty anxious about the whole thing, ha.

Every so often I get this sudden intense hunger spike. Usually happens early morning and fades on its own pretty fast, so easy enough to just push through. Used to get that same thing years ago on a different GLP1 option too.

15 pounds in 3 months at 1mg and the body working through the adjustment first before things started moving is a really common story. The 3 week mark on a new dose is usually too early to know if it is working. Give it more time.

If October is when a generic hits, that timing would make sense after the patent situation you're describing in Canada. The question is always how long US manufacturing catches up once there's actually a generic pathway. First-to-file generics tend to come in lower but not as low as they...

The CN origin is pretty much universal. Testing and vendor rep are the actual variables.

$11-13 per gram on cosmetic grade sites is consistent. The distinction matters mostly for reconstitution purity and testing documentation - the cosmetic listings usually skip both.

The rigid protein-first approach can make nausea worse when you are already sensitive. Eating something you can tolerate is better than hitting macros through discomfort. The rules matter less on bad days - getting anything in is the win.