Semaglutide for weight loss? Anyone?

Hong Kong Yanpep International
I don't have Crohn's personally but I know a couple people dealing with colitis, including someone who was on sema and had to take prednisone for a flare. Their doctor told them to pause the sema because the drugs might interact, and sema could just be ineffective while on pred anyway. Plus all that water retention from prednisone would probably hide any weight loss you'd normally see. My mom and partner both have colitis and sometimes need pred, and my friends know I'm on a glp1 so we talk about this stuff sometimes lol.
 
It's keeping my loss steady even as I've plateaued the dose and gotten closer to my goal weight. That's valuable to me - prevents the slowdown I might have hit otherwise.
 
The 15-20% average comes from the STEP trials at the highest dose over 68 weeks, but the distribution extended past that - some participants lost 25-30% or more. What influences outcomes beyond the average: insulin resistance level, dose titration, dietary quality, and duration. PCOS adds a layer here - the insulin sensitization effect means the metabolic starting point is already impaired, and correcting that often produces higher percentage outcomes. Losing more than 20% is common enough not to be unusual.
 
Non-diabetic semaglutide for weight loss is the majority of the forum's experience now - the prescription pattern shifted well ahead of the insurance coverage.
 
Non-diabetic use accounts for the majority of semaglutide prescriptions now - the STEP trials on weight specifically included both T2D and non-T2D populations. The weight loss outcomes for non-diabetics tend to be larger in absolute terms because the baseline A1c-correction effect doesn't compete with the appetite suppression for the mechanism.
 
The non-diabetic weight loss use case was where the clinical benefit became impossible to ignore - the trial data was strong enough that it changed prescribing norms significantly. The broader cardiovascular and metabolic benefits beyond weight have continued to accumulate in the follow-up data.
 
Three shots in now at 0.25. Honestly assumed placebo effect at first, but nope, this stuff is genuinely wild. Gone from massively overeating to barely getting enough down.
 
Sudden unexplained weight loss really deserves medical attention. Make sure you tell your doctor about every symptom you're noticing.

Don't assume that using the first compound briefly a couple years back has any bearing on what's happening now.
 
Really comes down to something simple. Track your calories. Weight loss follows the size of your deficit, full stop. This medication isn't some magic trick, it just makes eating less feel manageable, and that's the actual mechanism behind the results.

For certain people the appetite suppression and fullness hit so hard they physically can't eat past a low calorie ceiling, creating a massive deficit that translates to a couple pounds weekly.

A lot of people seeing strong results are still actively logging food and deliberately trimming portions to hit a target pace, rather than passively assuming the medication alone will handle the whole equation on its own. What typically trips people up during a deficit is food noise and cravings, and this drug class can quiet that down significantly. From there it's purely a matter of tracking intake and keeping the deficit at a sustainable level.
 
My point is that being diabetic or not makes no difference. Sema and tirz were both tested thoroughly in people without diabetes who had obesity. Your body does not care about the brand, either one is a really good tool for weight loss. Best wishes!
 
It did work for me. My baseline: healthy, plus years of regular weight lifting. Twelve pounds came off and I reached goal in 3 months of microdosing semaglutide, quite easily. The waist changed most, though my muscles look sharper everywhere too, my lifestyle and training results show more. Bottom line, totally worth it in my book. A small dose continues, affordable enough for me, while I hold my goal of 125 lbs at 5'3".
 
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