Semaglutide for weight loss? Anyone?

I don't have Crohn's personally but I know a couple people dealing with colitis, including someone who was on sema and had to take prednisone for a flare. Their doctor told them to pause the sema because the drugs might interact, and sema could just be ineffective while on pred anyway. Plus all that water retention from prednisone would probably hide any weight loss you'd normally see. My mom and partner both have colitis and sometimes need pred, and my friends know I'm on a glp1 so we talk about this stuff sometimes lol.
 
It's keeping my loss steady even as I've plateaued the dose and gotten closer to my goal weight. That's valuable to me - prevents the slowdown I might have hit otherwise.
 
The 15-20% average comes from the STEP trials at the highest dose over 68 weeks, but the distribution extended past that - some participants lost 25-30% or more. What influences outcomes beyond the average: insulin resistance level, dose titration, dietary quality, and duration. PCOS adds a layer here - the insulin sensitization effect means the metabolic starting point is already impaired, and correcting that often produces higher percentage outcomes. Losing more than 20% is common enough not to be unusual.
 
Non-diabetic semaglutide for weight loss is the majority of the forum's experience now - the prescription pattern shifted well ahead of the insurance coverage.
 
Non-diabetic use accounts for the majority of semaglutide prescriptions now - the STEP trials on weight specifically included both T2D and non-T2D populations. The weight loss outcomes for non-diabetics tend to be larger in absolute terms because the baseline A1c-correction effect doesn't compete with the appetite suppression for the mechanism.
 
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