B vitamins with GLP-1s?

[Sub-Q_Sammy]

Wondering if anyone is adding B9 and/or B12 to their compounded GLP-1 meds?

Do you recommend both, or only one?

Does it give you better energy?

Or, are you taking separate B9 or B12 shots or pills (with either compounded or pharmacy-bought GLP-1)?

Thanks!

 

[FastingBoss]

Stand-alone B9 or B12 injections are definitely a thing!

Some folks benefit from separate B12 shots, particularly if they have trouble absorbing it properly (like with pernicious anemia or GI issues). B9 is often supplemented by mouth, unless you need a shot for some reason.

Vitamin B12: Great if you're low, which can cause fatigue, anemia, and nerve problems.

Vitamin B9 (Folic Acid): Super important for cell stuff, especially for pregnant ladies or certain kinds of anemia.

Energy Levels

B12: Needed to make red blood cells and keep your nerves happy. If you're low, you'll feel tired.

B9: Helps with DNA and works with B12 to make red blood cells.

If you're actually low, these can boost your energy. If you're already good, you might not notice much.

 

[Quinn]

B12 doesn't seem to do anything for me. I've tried both kinds, and even with high doses, I don't feel more energetic. I know it helps some people, but maybe those people are using something else at the same time.

I think the compounders started putting B6 or B12 in to have a legitimate "compound" on paper and to reduce side effects, especially nausea. But it seems like whether it helps or not is different for everyone.

Sorry this doesn't help much!

 

[FastingBoss]

Could it be a quality issue? I remember a professor suggesting buying the cheap stuff directly from the manufacturer. Maybe the fancy packaging doesn't mean better ingredients?

 

[Mel11]

I get a separate B12 shot when I take my 10mg of Tirz. It's totally helped me with feeling less tired. Hope this helps!

 

[Sub-Q_Sammy]

Thank you! Are you only tired for a day or two after the injection? Or, are you tired all week?

 

[Mel11]

I'm really tired the day after the Tirz injection. But now, I don't get that tiredness after the B12 shot.

 

[ThinQuest928]

If you wanted a little extra push for weight loss and energy, I've found phentermine works well with tirzepatide. It's a stimulant, so it's not a long-term solution, but it does keep me energized. It's definitely not a necessity, but it's a nice bonus for both weight loss and feeling awake. Getting a prescription for it is pretty straightforward (at least in the US).

 

[Sub-Q_Sammy]

Do you mean B6, B9, or B12? Can you combine all three, or just two? How did you decide on B12 over B6 or B9?

 

[FastingBoss]

If you aren't getting enough nutrients from food, supplements are a must. Think about what vitamins you're missing from your diet and supplement accordingly.

Vitamin B6 (Pyridoxine)
Food Sources: Liver, meat, veggies, whole grains, legumes, nuts.
Functions: Amino acid metabolism, neurotransmitter synthesis, immune support, red blood cell production.
Benefits: Enhances protein and fat metabolism, nervous system health, immune function.

Vitamin B9 (Folate)
Food Sources: Leafy greens, legumes, citrus fruits, fortified cereals, liver.
Functions: DNA/RNA synthesis, cell division, red blood cell formation, nervous system support.
Benefits: Efficient metabolism, healthy cell growth, reduces fatigue, enhances stamina.

Vitamin B12 (Cobalamin)
Food Sources: Liver, meat, fish, dairy, fortified cereals.
Functions: Red blood cell formation, nervous system health, DNA synthesis, fat and protein metabolism.
Benefits: Boosts energy, maintains nervous system health, enhances energy levels.

 

[Mel11]

Sorry for the late reply! I use B12 Hydroxocobalamin. I love it!

 

[Sub-Q_Sammy]

Do you take the B12 and Tirz at the same time? Like, within minutes of each other?

 

[Yuki_56]

I've heard of people stacking peptides for different effects. Has anyone tried Sermorelin and Ipamorelin while on GLP-1s? I'm curious if it would help with energy or muscle preservation.

 

[Quinn]

I saw someone mention Tesofensine with their Tirz. I read on Reddit that it can give you a HUGE energy boost but might mess with your sleep. Has anyone else tried that combo?

 

[ThinQuest928]

Interesting about the Tesofensine. I avoid recommending anything that messes with sleep, since sleep quality is so important for overall health and weight management. But sounds like some people tolerate it well. Always good to start low and see how you react.

 

[SunnyJourneyLiving]

I'm curious about the Sermorelin/Ipamorelin stack that Yuki_56 mentioned. I found a thread on the other forum about it. Seems like some people use it to boost T levels after coming off TRT. Might be something to look into for maintaining muscle mass while on GLP-1s.

 

[Yuki]

I tried Tesofensine for a month alongside my GLP-1.

I read on Reddit that it can give you a HUGE energy boost but might mess with your sleep.

They weren't kidding! Energy through the roof, but sleep went down the drain. I stopped taking it because being tired all the time sucked more than the slight appetite control.

 

[Herculean_Habits]

I just say 'Zepbound' when people ask - shuts down the 'cheating' comments real quick. For most people I mention compound pharmacy. If they're genuinely interested I point them here. Close family who want it? I give them some of my supply and show them how to inject.