BP still high on GLP-1s?

Peptide_Hustle68

Peptide_Hustle68

Active member
Anyone else's blood pressure stay elevated even after significant weight reduction using these peptides? I'm on 20mg of that one BP med and 10mg of another, and my physician just switched one to a combo pill with a diuretic. My other vitals are solid, A1c was fantastic last check, but my BP readings are consistently around 150/90. Doc thinks it's likely too much salt. Trying to cut back, but wondering if anyone else has experienced this or has tips, diet or supplement-wise.
 
I had naturally high BP too. I switched meds a while back with good results.

Before swap from Losartan: 135/85
After swap to Telmisartan: 115/75

My current cocktail:
Amlodipine 10 mg
HCTZ 25 mg
Telmisartan 40 mg

I was considering swapping HCTZ for Chlorthalidone, but my doctor wants to monitor things as-is for now.
 
Just a few thoughts... I'm not a doctor, just sharing from my own experience.

If your blood vessels have stiffened due to long-term high BP, that may not be reversible. That's why managing BP is so crucial. There are many types of BP meds, each working differently. If one doesn't suit you, there are alternatives to try. Beta-blockers, for example, can help with anxiety.

Sodium's tricky. Too little isn't good, but too much is a problem. Track your intake to see where you stand. Aim for the sweet spot. Electrolytes are crucial for bodily functions, and low sodium can cause issues.

Also, Reta can elevate heart rate, potentially affecting BP. If you're new to it, maybe try Tirz first, given its anti-inflammatory properties.

Supplements like beet juice and hibiscus tea have shown promise. And don't underestimate regular walking!
 
I did experiment with stacking reta with tirz. Didn't really see a difference versus only high dose tirz, like 13mg tirz vs 7.5 tirz+5reta, but I'm willing to try again. I'll stick with it longer next time.

I'm guilty of eating lots of processed foods. I just started tracking sodium intake and it's not pretty. I've been walking for an hour almost every day since August and added some light strength training too.

I will ask my doctor about other meds. Thanks for the advice!
 
Glad to help. It sounds like you're already making good progress. I'm just speculating on how these GLP-1s affect BP. I haven't looked at trial data specifically for that. As long as it's not causing problems, that's good. (Still monitor it, of course.)

I'm in denial about my own BP sometimes. I take my meds, but I'm not as diligent with monitoring as I should be. I hate the idea of needing meds forever, and it motivates me to lose weight. My mom was on a ton of meds, and I want to avoid that.
 
I'm always looking for ways to lower my BP. It's genetic on my mom's side. I've always been active, even ran marathons, and I eat relatively healthy and take supplements, but nothing has helped. High BP showed up when I turned 40. I'm 63 now.

I've been on tirz since July to try to lose the extra 25 pounds that showed up after menopause. My brother lost a lot of weight this year to address high BP, type 2 diabetes, and high cholesterol. His BP hasn't budged even though his other numbers are great.

I'd really like to find a peptide stack that could help.
 
Beet root can reliably drop BP. I don't know if it'd interfere with your current meds. I read about it on Examine a while back and was surprised how well it worked... you can get tablets cheaply online.
 
I've tried beet root, but it didn't work for me, or I didn't take it long enough... I'm fine taking something long-term, but I'd prefer it to be natural over BP meds.
 
I'm with you. I dislike the thought of needing meds forever. I hoped weight loss would get me off BP meds, but no luck. Same for metformin. I don't see a good reason to stop metformin usage though.
 
My cardiologist didn't think my BP would change much. But it dropped enough for me to stop one BP med. BP is strange. Thin, healthy people can have high BP.

Weight loss improved my lipids, reversed my fatty liver, and lowered my A1C. Still, I take BP meds and use a CPAP. These meds are great, but not perfect for everyone.
 
My BP has decreased by like, 10 points. Still elevated, but slowly improving. The BP meds from my cardiologist barely did anything, except cause a side effect I manage with zinc. A few months on reta has been better than a year on BP meds.
 
Yeah, still on the BP meds, even though they don't seem to do much. My reta dose is 3mg, so it's not a huge dose impacting my BP.
 
It's common to need several medications for BP control. Getting a home BP monitor is a good idea; they're cheap. Deciding on medication changes based on just two readings is hard since one is borderline and the other isn't good. A bunch of readings help you average it out. Treat high BP now, even if you hope weight loss will fix it. It might not. Stopping BP meds is easy if they become unnecessary. Undertreated high BP is common. Research shows that tirz and sema reduce cardiovascular risk, but not yet for reta. Even with major weight loss, you might still need meds. Basic HTN workups check for secondary causes and organ damage. Also, cholesterol and blood sugar need checking.
 
A few thoughts:

Hypertension can be genetic, so weight loss might not help. Consider changing meds and getting a 24-hour BP test. Cut out sodium. Check your BP device's calibration. I use Omron.

Kidney issues can also cause it. Regular checkups should include exams, blood work, urine, and ECG.

And remember, clinic readings are often higher. Do a 3-day home test, morning and evening, three times per session. Happy Holidays!
 
I tried the no-sodium, protein, veggie, no-carb route. In about three months, I ended up with hyponatremia. Sodium was 118, leading to an ambulance ride and a hospital stay. I never thought that could happen eating so clean... Just my story; we're all different.

Next step is to switch BP meds and maybe add a second. I need to find a balance. Thanks for all the input!
 
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