The third-shot insomnia pattern is real and tends to normalize by shot 5-6 as the body adapts to the changed metabolic baseline. The 'tired but wired' state is a known early-phase response, particularly in the 24-48 hours post-injection. The brain-space shift - not thinking about food - tends to settle in around the same window.
The olfactory route argument is the strongest case for intranasal over subq - the BBB question is real even if the placebo component is hard to isolate. Most people who switch to IN report a faster and more distinct cognitive effect, which is consistent enough to be more than placebo.
The day 5-7 window returning food appeal is partly why some people split to twice-weekly - it smooths the concentration curve and keeps the noise floor lower throughout. The 2-4 day quiet zone is the cleaner signal of what full suppression actually feels like, and the mid-week creep back in is what you're adapting to rather than fighting. Using that quiet window to reset food associations rather than just noting the absence is where the longer-term change tends to happen.
The day 6-7 hunger uptick on weekly dosing is consistent enough across people that it's basically expected - the suppression wears down toward the end of the cycle for most. The non-linear scale weight thing is worth internalizing early: daily numbers bounce around by design and weekly trend lines are the actual signal.
The 'wait, this is what normal feels like?' realization after the food noise quiets is genuinely disorienting in the best way - most people have no reference point for brain function without that constant overlay until it's suddenly gone. It changes your understanding of what was actually happening before.
The split dose approach giving a better sweet spot is a useful protocol note for the OP who's noticing the day 5-7 hunger rebound. Timing variation can smooth out the weekly curve better than just going higher on the dose. What's the sweet spot you landed on and how long did it take to find it?
The predictable end-of-cycle appetite increase before injection day is data you can plan around rather than fight - knowing the hunger is coming on a specific day and having food prepped for it makes it less disruptive. The zero-desire days earlier in the cycle are the reset that makes the end-of-week manageable.
This is exactly why I switched to injecting every six days instead. Take a slightly smaller dose to land at the same weekly total. Genuinely enjoy the six-day rhythm, get noticeably hungrier for a stretch beforehand, use that window to hit my weekly calorie targets, and know eating tapers off again right after the next shot. Works really well for me overall.
Same thing happens to me. Especially right after taking the shot, food just holds zero appeal those first couple days, I basically have to make myself eat something so I don't go completely without.
Odd, I've always injected in my stomach with no trouble, though I do get hunger days. Some people said thighs work well, so last Sunday I tried the thigh. Then yesterday I was famished the entire day, nonstop eating. Made me think. Might try the thigh again, or maybe revert to the abdomen. Mind tricks.
No doubt about your experience, this is simply my routine. One shot weekly, and in my view the suppression never fades. 46lbs in 19 weeks, an average of 2.4lb weekly.
My interval is 12 days and that suits me. Once I stretched to two weeks, but hunger hit hard by day 12 and I returned. A friend of mine goes 3 weeks apart and calls it fine, though nausea and the like are worse whenever she finally injects. Everybody's different, you just have to test what works. Ten days has worked best for me over the past six months or so.