CagriSema flop?

SnackNoMore

SnackNoMore

Well-known member
Well, Novo's CagriSema didn't beat Lilly's Zepbound in the Phase 3 trial. Novo shares took a hit. CagriSema got folks down 23%, while Zepbound hit 25.5%. Looks like Zepbound is still king.
 
Those weight loss numbers are pretty similar. I wish they'd show dexa scans so we'd know how much fat vs. muscle is lost. Knowing the composition is way more useful than just the total weight. I hear a lot of people lose 25% muscle mass
 
CagriReta is the real deal! I'm doing 4.25mg of reta on Sundays and 750mcg of cagri on Wednesdays. It's working great for me.
 
The results are similar on paper, but the side effect profiles are different. Tirz is likely more favorable. Sema was the original, but it's outdated now. Cagri was new, but not a selective amylin agonist. Amylin agonists (like Elora) have more tolerable side effects. CagriSema is like a compromised drug. Stacking Reta with an amylin agonist like Elora might be the best combo... if you want to get back to your starting weight.
 
We don't have any safe, effective, or approved myostatin inhibitors yet,
Light_Life said:
Why don't people stack a myostatin inhibitor with a GLP-1 agonist? That way, you could keep or even gain muscle while losing fat.
Click to expand...
Many are waiting. There are a few in development, but they're monoclonal antibodies and will be very expensive and not easily available. Some peptides are marketed as myostatin inhibitors, but their results and safety are questionable. Enobosarm (Ostarine) has been tested with sema and seems to help people keep muscle while losing fat but is still just phase 1 data. Ostarine has liver and lipid side effects.
 
Sorry to anyone who owns Novo Nordisk stock. I was in the trial on the tirzepatide side. I dropped around 30% of my weight and got jacked from lifting.
 
I still love sema so much.

I'm in week 3 of sema 3mg + reta 10mg. It's amazing.

All GLP drugs are about the same for appetite. Tirz and Reta give you more energy, but not by much. If Reta didn't exist, I'd be happy with just sema.

Is sema obsolete? No, just less popular, which is good because it's cheaper!
 
Me too. I'm not ready to stack GLP/GIPs. Sema was good to me and then I maxed out. Wish I'd known about the higher dose trials back then. Now I'm stocked up on Tz for a while.
 
Been hearing whispers about SLU-PP-332 on some forums. People are saying it can replace Clen and DNP, with less toxicity but still good non-stim effects. Anyone else heard of this?
 
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