Didn't Feel Anything Right Away? Help!

Definitely worth flagging to your doctor. Yeah, GI complaints get mentioned constantly, but suddenly getting emotional and crying unprompted? That deserves attention. Could be coincidence and unrelated to the med, but if the pattern continues or worsens, talk to them sooner. If you feel unsafe emotionally at any point, reach out immediately.
 
Two days in at 0.5 is very early - most people don't notice real effects for 2-3 weeks. Stomach upset is actually a good sign. Give it time.
 
Not feeling anything in the first two days on a starter dose is normal. The effects build over weeks. No side effects early is a good start, not a sign it is not working.
 
SS-31 and MOTS-c work at the mitochondrial level - effects show in energy and recovery over weeks, not as a felt daily sensation. The benefit usually becomes clearer in hindsight.
 
GHK results vary widely. 6 weeks at 3mg showing nothing is a valid data point. Skin is the most variable outcome.
 
Two days at 0.5mg is the beginning of the timeline, not the result - most people don't notice appetite changes until week 2-3, and the quieting of food noise can be subtle enough that you recognize it in retrospect rather than as a distinct event. Discouraged at day 2 is a premature read. The stomach upset is the medication working; the hunger signal change follows the GI adjustment, not the other way around. Give it 4 weeks at 0.5mg before drawing any conclusions about whether it's working.
 
Day 2 at .5mg is genuinely too early to draw a conclusion - the suppression effect takes time to build from a standing start, and the forum narrative about feeling it immediately is a combination of people who are unusually sensitive and reporting their most notable early experience, not a representative average. The quieter starts are actually more common than the immediate dramatic response would suggest. What to watch for in week 2-3: fullness arriving faster than expected at meals, a slight reduction in how much food is on your mind between meals, reduced interest in snacking. These tend to arrive quietly and are easy to miss if you're looking for a dramatic signal. The obsessing about whether it's working is itself a signal of the pre-dose baseline anxiety - that pattern tends to shift as the medication builds.
 
the fatigue without nausea presentation is a real pattern that doesn't get as much coverage as the nausea story - the medication changes the metabolic and neural load in ways that can land as tiredness rather than GI effects for some people. the absence of nausea for someone who typically vomits with other triggers is also notable; the GLP-1 antiemetic effect seems to be real for some people even while the weight loss mechanism is active
 
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