Dihexa for cognitive issues?

Vial_Cake

Vial_Cake

Active member
I feel like I'm constantly digging into this, but I'm trying to figure out Dihexa for someone close to me that had a brain injury from lack of oxygen. They had cancer, had an operation, nearly died a couple times and was in a coma for a while. They now struggle with remembering recent things, problems thinking clearly, and difficulty with precise movements. The doctors seem satisfied with their current condition and aren't interested in trying new things. They didn't even want to try oxygen therapy because its experimental and insurance wouldn't pay. I think they would be more proactive if it was their family. Considering Dihexa and similar drugs seem to help the brain make new connections and improve memory, I'm seriously thinking about it. But I do have concerns.

Many mention the possibility of increased blood vessel growth and previous cancers. Are there any studies I should read about this? It doesn't have to be specific to Dihexa, but for any similar peptides. The person I'm helping won't be able to describe any changes they feel, so it would be up to others to observe them. We've put off GLP1 meds for similar reasons. I can't imagine having bad side effects and not knowing what they are because you don't remember taking anything.

Additionally, if Dihexa seems like a good idea, any recommendations for how to get it in pill form would be great.
 
I'm really sorry to hear about this. That sounds like a really tough situation. According to an AI, there's a definite chance of reactivating any sleeping cancer cells and Dihexa has that risk. Also, all studies so far have been on rats, not people. It's a pretty new peptide. Some of the studies have been taken down. The AI said:

The HGF/c-Met Connection (The Main Risk)

The biggest issue with Dihexa is how it works. It turns on the HGF/c-Met pathway (Hepatocyte Growth Factor).

In the brain: This helps the brain make new connections between nerve cells, which is why people are studying it for problems after chemo or Alzheimer's.

In cancer: The c-Met receptor is often found in large amounts in several types of cancer, like some lymphomas. When you turn on this pathway, it can help cells survive, move, and tumors grow.

The Problem: Taking something that strongly activates a growth pathway might "wake up" cancer cells that are dormant or cause it to come back.

Important:

You should talk to the oncologist before starting Dihexa. Because of the person's history with lymphoma, a specialist needs to approve any substance that boosts growth pathways (HGF/c-Met). They need to know about the specific type of lymphoma and the current status (in remission or still active).

Here's a link with more info about dihexa, with links to studies:

https://pep-pedia.org/peptides/dihexa

I've seen a few places selling this.
 
My first thought is, does the patient have the mental capacity to agree to a treatment, understanding the possible risks and rewards of a peptide that hasn't been officially approved for human use, given they have a brain injury?
Even if you're legally able to make treatment choices for them, whether officially or unofficially as a close relative, using it without clear agreement could put you at legal risk if something goes wrong because of the peptide, or if something happens that's thought to be related to the peptide.
 
I'm not avoiding that moral issue either. That's why I'm getting information first. If I decide to give it to him, I'll discuss it with him and his legal guardian many times until he can confirm later that we talked about it and he's okay with it. He's not dumb! He's intelligent! He used to be an expert in his field. He just...can't remember recent things. I'm not hoping for miracles, but if anything can improve his life, I'll check it out.
 
Thanks Cut-Wine! I'll read those. I also read about Fosgonimeton, which is a drug based on Dihexa and the human studies they've done. They saw some improvement, but the studies stopped for various reasons, like small sample sizes and the placebo groups also showed improvement. That's what I was referring to with human trials. And I'm very concerned about the cancer coming back. If I were the patient? I'd try it immediately.
 
I really appreciate it. I'm new here. You don't know me. Thanks for caring enough to comment. It's definitely something to consider. It's a difficult situation. I'm not his official guardian yet, but I will be in the future. And I don't want to treat him like a lab rat, especially one that can't consent. If he can't agree, I won't do it. And you've helped me decide on that.
 
I already thought about those. Cerebrolysin, especially, but I've already waited for a month and a half for my order. Also, it and the Russian peps are for making existing brain connections better. I read that the typical way to do it is Epitalon followed by Cerebrolysin for that, but Dihexa is made to repair broken brain connections, which it sounds like this person needs. Dihexa is the heavy hitter but has equal risks, based on their past.
 
I was also considering Cerebrolysin. You can find info at Cerebrolysin.com and in this thread. According to the site, "Cerebrolysin® is a multi-modal neuropeptide drug with a fast onset of action that helps to regain and maintain the independence of patients suffering from stroke, TBI, dementia and cognitive impairment." When it asks if you're a medical professional, you are. I'd also talk to the doctor about getting them into clinical trials.
 
I hope our cerebrolysin orders show up soon [emoji face with tears] It seems there's a big delay because of the holiday.

I'm not sure Epitalon would be my first choice here. I'm on my second round and haven't noticed much brain change, except a slightly better mood. Cerebrolysin seems more promising, at least from what the website says.
 
I'm so sorry you and your family member are dealing with this. If it was my relative, I'd also be angry that the doctors were giving up on finding solutions. See my answers above for my ideas.

How long ago was their operation and coma? Does the patient eventually remember stuff that gets repeated a lot?
 
I think it depends on how old you are and how much damage there is to the signaling pathways to notice the effects. I thought it helped me, but I don't think it's for serious damage like this, but I'm not a doctor from Russia.
I don't think it would be the right thing to start with for them. Cerebrolysin would be a good choice, along with dihexa. I was only thinking about how long the wait is. I think mine got held up somewhere. We'll see.

Edit: The guide says the suggested amount is 20-50 ml given by IV every day for 2-3 weeks for strokes or brain problems. I don't know how they'd do that.
 
It happened back in 2020. It's been about 4 years and he's had slow progress followed by setbacks. Sometimes he'll remember things from the previous day, and sometimes he'll ask you six times in a half hour if he's eaten lunch. The brain is complex and I am cautious about changing it, but if something might help, I want to research it.
 
Anela, who is known for GHK-cu, has a thread talking about how epitalon improved her frontal lobe issues from a brain injury with EEG results. I don't think she's lying, at least that's what I believe.
 
Some other ideas that are different:

Shrooms: Psilocybin is known for its neuroprotective and anti-inflammatory effects on the brain. Some think oxygen-related brain damage is related to brain inflammation. Shrooms also help the brain be more flexible. This is more experimental, but could be worth trying. If you do, I suggest microdosing every other day for a month to avoid mind-altering effects.

Reta: It's more than just for losing weight. It reduces inflammation, improves how the brain uses sugar, and protects the brain. If weight loss isn't needed, I think a low dose to start would be enough to see if it helps. If you're worried about cancer, studies in mice show that Reta can starve tumor cells.

GHK-cu (already mentioned) and TB4 are both known to help the brain recover and repair itself.
 
Yeah, her Reddit post is why I looked into it. We have similar problems. She does it for 10 days a month. I might try that eventually, after I get a baseline.
 
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