Doc wants me to stack Ozempic with Zepbound?

T

ToneLean

Well-known member
Saw my endocrinologist yesterday. I'm currently on Zepbound 15 mg (using a similar product to accumulate a supply). My BMI is around 26 and he wants it lower. It’s been a slow process since shifting from Wegovy to Zepbound. He suggested adding a bit of Ozempic, like .25 mg, and seeing if it boosts things. I mentioned I had some 2.4 mg Wegovy injectors leftover, and we considered using those.

Figured those stacking or contemplating stacking might find this interesting.
 
Since sema binds super well to GLP-1, it's not totally nuts, but maybe not the best first move. Metformin can help your body use GLP-1 better, plus it helps with blood sugar and appetite... Or, you could use bupropion to speed up your metabolism and curb your appetite while giving you more energy. Lots of options before going that far.
 
I've been at this for quite some time now. Was on Metformin early on. The knee pain was awful (thought it was the statin I was on). Doc said nah, it's the Metformin, and stopped it, knee pain went away.

I also took Wegovy and Contrave (which contains bupropion) for several months; no go, still have half a year's supply unused. Started Zepbound back in the summer.

As I get closer to a healthy BMI, the harder it gets. My doctor is estimating about a pound lost each month now.

I'm a nurse, and this endocrinologist is truly the best, most knowledgeable, and most thorough doctor I've ever met. He's definitely not just writing scrips and running—I trust him completely. He also trusts my ability to safely manage my doses.
 
Wish the landscaper would work harder on the weeds!

Most doctors think a full exam is just listening to your lungs and heart for a sec. My endo actually does a thorough assessment, feels my thyroid, looks at my skin, and even uses a tuning fork on my feet. Ordered a lung CT, thyroid and breast ultrasound, and tons of lab work. He’s practically my primary care now since I can't find a good one. The last one just wanted to sell me vitamins.

Being a nurse, I think I know what a good doctor should be. 'Mow, blow, and go' describes most of them.
 
Good to hear a doctor is cool with stacking semaglutide. I won't be mentioning it when I start adding some sema to my Zepbound. I use Zepbound 'cause insurance covers it; otherwise, I'd go with compounded or the gray market stuff. As I understand it, semaglutide has a much stronger GLP-1 effect compared to tirzepatide. I think dionysos knows more about this than I do.
 
Interesting approach. Has your doctor considered other options to optimize your current Zepbound dosage before introducing another GLP-1 agonist, ToneLean? Perhaps splitting doses or adjusting the timing could yield better results without the added complexity of stacking.
 
While stacking GLP-1 agonists *might* offer enhanced weight loss for some, it's crucial to consider the increased risk of side effects. Things like nausea, vomiting, and diarrhea could become more pronounced. We also don't have long-term studies on the safety of combining these medications. Always a risk/benefit assessment to be made.
 
I feel like doctors are so quick to add more drugs! I'm on a lower dose of Ozempic and focusing more on diet and exercise. It's slower, but I feel better overall. Has anyone tried that first before going straight to stacking? Just curious!
 
I wonder if anyone has combined GLP-1s with something like sermorelin. I have heard anecdotally that some using sermorelin report improved sleep and energy. Maybe it would offset some of the fatigue some get from these weight loss drugs?
 
Lean_Pizza said:
I wonder if anyone has combined GLP-1s with something like sermorelin. I have heard anecdotally that some using sermorelin report improved sleep and energy. Maybe it would offset some of the fatigue some get from these weight loss drugs?
Click to expand...

That's an interesting thought! I've heard sermorelin can boost GH release. Seems like a totally different mechanism though, so I'm not sure if they'd directly counteract the fatigue from GLP-1s. Maybe indirectly, through better sleep?
 
To Lean_Pizza's point about sleep and energy, have you looked into optimizing your testosterone levels? Some folks using TRT plus hCG report that adding nandrolone can sometimes reduce the perceived effectiveness of the hCG. This might impact energy levels and overall well-being. Just thinking out loud here, as it could be another factor.
 
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