-
This forum is for informational purposes only and does not provide medical advice. Read our Medical Disclaimer. | Privacy | Terms | About | Cookie Policy | Editorial Policy | This site may contain sponsored content and affiliate links.
Dose escalation: be bold?
- Thread starter GutCrew
- Start date
ThighShotHigh
Member
One of the studies referenced (https://www.sciencedirect.com/science/article/pii/S1550413122003126) had a unique titration schedule: 0.1mg, 0.3mg, 1mg, 3mg, 4.5mg, 6mg. It was probably one of the earliest, since it included both obese mice and human subjects.
In humans, 0.1mg, 0.3mg, and 1mg didn't show significant weight loss after one dose. But 3mg, 4.5mg, and 6mg did, and the weight loss lasted for up to 45 days after that single dose!
I'm guessing that's why the big trials started at 2mg.
In humans, 0.1mg, 0.3mg, and 1mg didn't show significant weight loss after one dose. But 3mg, 4.5mg, and 6mg did, and the weight loss lasted for up to 45 days after that single dose!
I'm guessing that's why the big trials started at 2mg.
Bee-IMO
Well-known member
Replying more to the original post than to the comments.
There's a good reason to increase the dose to or towards the standard maximum dose, and the science backs it up.
Most people on these meds have significant obesity, which doesn't apply as much to bodybuilders, younger people, or those who are just overweight. But people with long-term significant obesity are often at higher risk for heart disease, stroke, high blood pressure, impaired glucose tolerance or diabetes, high cholesterol, and low exercise levels.
GLP meds (less proven for retatrutide) reduce the risk of heart attack, stroke, heart failure, cardiovascular death, and death from all causes. They also lower blood pressure, blood sugar, and cholesterol. Since these are the main causes of death and disability as we age, GLP meds can help you live longer and healthier. Semaglutide's effective doses are 2.4mg or lower (if not tolerated), and Tirzepatide's is 15mg. The improvements are partly from weight loss, but the reductions in these levels and events happen even without much weight loss.
GLP meds may also reduce the risk of Alzheimer's and some cancers, but they might increase the risk of thyroid and kidney cancer.
Lower doses still have benefits, but they're likely smaller. Proving these effects requires large, long, and expensive studies, so it's unlikely they'll be done at lower doses.
TLDR: Taking GLP meds long-term reduces your chances of dying from bad things as you get older. There's no reason to believe lower doses are as effective.
Increasing doses slowly is generally a good idea, especially without medical supervision (which is true for many here). But for older people with significant obesity, there are good reasons to reach the standard maximum dose.
There's a good reason to increase the dose to or towards the standard maximum dose, and the science backs it up.
Most people on these meds have significant obesity, which doesn't apply as much to bodybuilders, younger people, or those who are just overweight. But people with long-term significant obesity are often at higher risk for heart disease, stroke, high blood pressure, impaired glucose tolerance or diabetes, high cholesterol, and low exercise levels.
GLP meds (less proven for retatrutide) reduce the risk of heart attack, stroke, heart failure, cardiovascular death, and death from all causes. They also lower blood pressure, blood sugar, and cholesterol. Since these are the main causes of death and disability as we age, GLP meds can help you live longer and healthier. Semaglutide's effective doses are 2.4mg or lower (if not tolerated), and Tirzepatide's is 15mg. The improvements are partly from weight loss, but the reductions in these levels and events happen even without much weight loss.
GLP meds may also reduce the risk of Alzheimer's and some cancers, but they might increase the risk of thyroid and kidney cancer.
Lower doses still have benefits, but they're likely smaller. Proving these effects requires large, long, and expensive studies, so it's unlikely they'll be done at lower doses.
TLDR: Taking GLP meds long-term reduces your chances of dying from bad things as you get older. There's no reason to believe lower doses are as effective.
Increasing doses slowly is generally a good idea, especially without medical supervision (which is true for many here). But for older people with significant obesity, there are good reasons to reach the standard maximum dose.
DoseIRL709
Well-known member
Has anyone skipped doses for vacation? What was it like?
SulphurBurpSurvivor
Well-known member
DoseIRL709 said:
I missed a week before a trip to Asia. My stomach was NOT happy at every temple. Thankfully, at least the toilets were super-clean and fancy. If I had to deal with that, Asia was better than Europe!
research-nerd
Well-known member
GutCrew said:
I'm new to all this, but what exactly are those peptides supposed to do?
Clean-Boss
Active member
I skipped a dose once for a surgery and honestly felt no different. I think it stays in your system for a while.
Technically you might not know until tomorrow morning. The half-life is short but effects linger, so a 0.5mg+ top-up might be smarter than a full dose within 24 hours. 2mg seems too high for anyone. As a guy, I'd stick to 1-1.5mg max within 24 hours. The dosing is the biggest PT-141 issue since it's unpredictable without short duration.
Izzy_2000
Member
been on mounjaro 7 months now. started 2.5 for 3, then 5 for 2, then 7.5 was rough - red welts at the site, itching, bruising for a bit. stayed on 7.5 for 3 months and now it's kinda stopped working. starting 10 tomorrow and hoping it goes smooth. also type 2 diabetic. anyone else do the 10 mg jump?
dose-day-dread
Well-known member
Bold can backfire if your body hasn't held a baseline yet. I crept up 1.25 -> 2.5 -> 4 over 10 weeks instead of jumping monthly. Side effects stayed mild and I kept the appetite suppression curve intact. The folks I see rebound hardest are the ones who escalated fast then crashed back trying to stay there. Patience compounds, boredom on the lower end is the price.