I was on it a year and lost about 50lbs, then a supply hiccup meant about 6 months off and I regained 40lbs. Back on at double the previous dose, loss is really slow, if any. Food noise is still curbed and my intake is way lower than when off it, but just to maintain or progress I have to watch calories closely and exercise almost daily. I think early on I lost lots of muscle since I wasn't training, which hurt my daily calorie burn, so regain was all fat. A few months back on and I'm down 15lbs again, but it's a lot more work than year one. For context I'm heavy, 275-300. Plus side: my a1c looks great, because two years back I sat in the pre range.