Gallstones from weight loss? Ouch!

Peptide_Journey

Well-known member
Hey everyone, I think we all know that super fast weight reduction is usually a bad idea. I didn't listen, and paid the price. Just wanted to share my story as a warning since I know many of us are on similar journeys via similar meds.

I had great results with my protocol, dropping a significant amount of weight pretty quickly. I'm talking nearly 60lbs (around 27kg) in only 7 months. That's over 2lbs per week, which is not advisable!

One day, I woke up from a nap with a crazy sharp abdominal pain. It was like nothing I've ever felt before. I was pacing around, trying to get comfortable, but the pain just kept building until I was screaming and thought I was dying. Off to the ER I went, and the ultrasound showed...

My gallbladder was packed with stones. This was my first biliary colic attack. For those who don't know, the gallbladder stores bile produced by the liver, which helps digest fats. Gallstones can form, which really complicates things.

If you know the pain scale from 0-10? Biliary colic is a solid 10. Seriously, you don't want this. It's pure torture. Even nurses who've given birth told me it was just as bad.

Morphine barely touched the pain. Each attack lasted 4-8 hours. After the first, they kept coming back almost daily. The only real fix is cholecystectomy (gallbladder removal). ER surgeons usually won't operate right away, so I had surgery scheduled about 2 weeks after my first attack.

Of course, things escalated. One of my stones got stuck in the common bile duct. I was admitted to the hospital after multiple ER visits. My blood work showed my liver was in distress and things were getting serious. They had to perform an ERCP to remove the lodged stone before they could remove my gallbladder.

Luckily, the stone dislodged after 10 hours in the hospital. The surgeons bumped up my surgery, and I got it done just two days later. The surgery went well, but it's still surgery. I needed two weeks off work to recover.

My warning is this: rapid weight reduction is a major risk factor for gallstones. It's not necessarily a direct side effect, but every doctor I spoke with said they're seeing more gallbladder issues with patients using similar meds.

If you want to avoid this, take it seriously. Reduce weight SLOWLY. Give your body time to adjust.

My life has changed because I'm no longer obese, I'm exercising, and I feel great. But it came at a significant cost. These meds are a tool, and they must be used wisely to avoid complications.
 
I'm so sorry you went through that, it sounds awful! My doctor and everything I've read says that losing 1-2 pounds a week is a good, sustainable rate. Hopefully, you're feeling better now!
 
That makes sense. I can definitely see an increase in these types of issues. But, remember, obesity itself also contributes to gallstone formation, so combined with really fast weight loss, some people are at an even higher risk.
 
I've been on mine since March and I've steadily shed about 6-8 lbs per month. That's about 27lbs total. I realize it's not super fast, but I'm happy to take it slow if it means I'm (1) more likely to keep it off for good and (2) avoid awful side effects like these.

A win is a win, regardless of how long it takes.
 
I'm curious, were you overweight for a long period? Or dealing with diabetes? High cholesterol? Were you over 40? Have you been pregnant or on birth control? A diet low in fiber? Just trying to figure out all the things I should be mindful of. Thanks!
 
I've only dropped 10-12 pounds in the last three and a half months. Your story makes me feel better about taking it slowly. I'm over 65 and I knew losing weight would be more difficult after menopause. I'm not increasing my dose quickly because of uncomfortable side effects like constipation. I think slow and steady will be best for me!
 
Thanks for the warning! Luckily, I had my gallbladder removed way before ever trying this medication... But, I remember the pain, and I was also sure I was on the verge of death!! Thank you for sharing your experience.
 
You are absolutely right that taking it slowly is beneficial. As I said, I don't have a gallbladder anymore. I also went through the same agonizing pain that you had, and it was horrific. It took a whole year for me to get a diagnosis and treatment... which was surgery. This was way back before they had scoping procedures, so they cut right through all the abdominal muscles. Pretty much everyone in my family has had it removed since we all make stones. I just hope there aren't any issues now that we don't have gallbladders and are taking Semaglutide. That's what I'm worried about.
 
I had mine out a couple years ago after experiencing the worst pain ever (like you described). I think these meds don't actually cause stones, a bad diet does. The medication may speed up the process slightly, but stones take around 10-20 years to form.

Essentially, it makes something that was probably going to happen, happen a bit faster.
 
BG_Checker said:
Just trying to figure out all the things I should be mindful of.

To answer your earlier questions, I was overweight for a long time, but not diabetic. My cholesterol was a little high, but nothing too major. And I'm under 40, never been pregnant either. I did eat a pretty low-fiber diet, though.
 
Interesting about the IBS stuff... I'm always bloated and gassy. Maybe this med could help BOTH my weight and my gut? Worth a shot!
 
I've also read about some people needing to pee a lot more when starting these meds. Apparently, that usually stops after a few days as your blood sugar stabilizes.
 
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