GLP-1 cost analysis?

W

Wild_AF

Active member
Huge thank you to everyone for being so helpful and sharing your knowledge! It's really appreciated.

I've been pretty happy with sema, and I dabbled in tirz at market price but I think my dose wasn't high enough (around 10mg per week). So I went back to sema at about 1.5mg each week. Debating going higher, but don't want to build up too much of a tolerance.

It kinda feels like the drug companies are pushing the newer, pricier GLPs for profit, and sema is getting less attention. I was looking at this study that didn't even include sema, only lira/tirz/reta; tirz seemed better for glucose and reta for liver/kidney/heart.

No offense intended, everyone's different... but is part of the rush to the latest GLP just like getting the newest phone? For me, sema worked better than tirz because of the dose and price. Are there liver/kidney advantages with newer ones that I'm missing?

I'm thinking of trying tirz again using a grey market source.

Has anyone compared the official study data on percentage fat loss vs. the cost of each GLP? From what I've seen, the differences aren't massive, but maybe my math isn't up to par. Is there a clear winner in cost/benefit?

I've also heard cagri is amazing, but some people say it's not much of an enhancement when stacked with sema?

I don't totally trust the drug company studies, but those are the main data points we have besides community experiences.

So, tl;dr - has anyone crunched the numbers to find the most cost-effective GLP, comparing % fat reduction to price? Thanks a bunch!
 
Ask 100 people, get 100 opinions! haha

Tirzepatide has been great for me. The price is good and dropping. I saw two 40mg kits for a good price with free shipping (I believe). That's less than 400, amazing!

I don’t think Cagri works well solo but it does contribute when stacked with existing GLPs.
 
If sema is working for you, stick with it. I had a pharma rep friend who always said if a patient was doing well on a competitor's drug, there was no reason to switch. Generally, people tend to lose more weight using tirzepatide and retatrutide. However, both usually cost more than semaglutide.
 
You're right, that's why I'm leaning towards staying with sema.
But there's still that fear of missing out (FOMO). Am I missing something or overlooking something?
Specifically the liver/kidney benefits of reta... or maybe a price analysis will demonstrate tirz/cagri is better when taking fat loss percentage into account.

Or maybe reta/tirz targets belly fat more effectively than sema. Maybe I should combine them.

Anti-inflammatory and neuroprotective effects are also important, so if one is much better, it might be worth paying more.

Everyone's experiences vary! Some claim cagri is a weight loss monster; others are unimpressed.

A year's supply of tirz for that price is a steal compared to over-the-counter!
 
What payment options are accepted? Two 40mg kits gives 80mg, enough for about 26 weeks at 30mg weekly.

53 weeks at 15mg weekly for $350 with free US shipping, plus maybe $50 USD shipping elsewhere.

That may be as competitive as current deals on another platform. They offer free shipping above a certain amount and a 60mg kit. The newer deal is likely better for US residents.

Do they reship if a package goes missing? Or offer refunds? I'll need to check with the other source to see if they reship too.
 
Also, do you guys take metformin alongside your GLP-1? I've noticed many people in the biohacking/longevity circles advocate for metformin due to its potential longevity benefits.
 
I don’t think anyone is dosing 30mg a week. That’s double the highest recommended dose. Pretty sure tests are only performed at 20mg max.

I use AliBaba Pay, but they may accept Crypto too.
 
If sema is managing your weight effectively, I wouldn't recommend switching to reta or tirz based solely on unconfirmed health benefits, especially if cost is a factor.
 
I did a quick cost-benefit analysis and posted it somewhere else.

Of course, this can only assess general trends. Individual responses vary.

If you want to compare prices, I suggest making a spreadsheet. You can quickly figure out the monthly cost at min/max dose based on the kit price.
 
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Studies show semaglutide generally does not result in as much weight loss as tirzepatide. Less conclusive studies suggest retatrutide leads to more weight loss than tirzepatide.

Semaglutide works well for a lot of people. In the tech world, it might be like the latest iPhone if other companies hadn't made such strides. Semaglutide is also very affordable if you go off-label.
 
Strangely, tirz wipes me out (even at a small dose!), but sema doesn't. A lot of people hype up tirz, but I'd recommend sema first - you can always switch if you have problems or plateau. Less money wasted if you do switch.
 
I get that some people have to base their decisions on what they can afford. I just think the cost difference is less than a fast food meal each week. Effectiveness and sides are more important.

Based on current prices for one vendor.
 
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