GLP-1 Headaches: Dehydration?

C

Charlie_11

Member
Anyone else getting headaches that feel like dehydration the day after a peptide dose? I'm on 5mg of Tirz and 0.5mg of Sema currently.

It's a throbbing headache at the base of my skull that radiates into my neck. OTC meds usually help, but I worry about rebound headaches. I'm wondering if the slowed digestion also slows water absorption, so when I workout and sweat after my weekly shot, I get dehydrated.

Is it possible that slower gastric emptying messes with hydration?
 
I haven't thought about it that deeply, but that makes sense intuitively. I'm just trying to drink way more water and electrolytes!
 
Totally makes sense. Do you find yourself peeing a lot when you're hydrated? Electrolytes are key for me. Maybe try upping your water intake the day before and the day of your injection, with some electrolytes mixed in. Pre-hydration is where it's at!

Also, how much water are you aiming for each day? I heard you should drink half your body weight in ounces. I weigh around 200lbs, so I try to drink 100oz daily.
 
I have a bad diet soda habit. It makes me go to the bathroom a lot, so I assume it's a diuretic. I'm cutting back and switching to water.

I drink water throughout the day, but I don't track it. I should start. I've been using Gatorade powder from Amazon when I feel a headache coming on. Pre-loading is a good idea.
 
Not a dumb question at all @Charlie_11!

Slowed digestion for sure plays a role. It not only slows the absorption of nutrients, but also water. Plus, feeling full makes it hard to drink a lot.

I read that we get around 20% of our water from food. Since starting GLP-1s, I'm eating maybe half of what I used to. I always bring home leftovers from restaurants!

So, GLP-1s can cut water intake by like, 10% right off the bat. And then add the discomfort of drinking a lot with slowed digestion... it's surprising more people don't have dehydration issues.

I'm even wondering if my constipation is related to not drinking enough. 🤷🏻‍♂️
 
I stock up on those electrolyte packets from Costco. They're a good deal, especially when they're on sale. They're convenient and work well.
 
GLP-1s don't just curb appetite, they also seem to reduce thirst. It's easy to drink less without realizing it, so you have to be mindful about staying hydrated. And ironically, weight loss can actually increase your body's fluid needs. Electrolytes can help your body absorb the water more efficiently.
 
When I first started Tirz, I was getting low blood pressure and feeling dizzy. For months now, I've been having one LMNT electrolyte packet every morning in about 69 ounces of water. Rain or shine. I try to finish it before my coffee. Then I drink another 74 ounces of water during the day, minimum. At least 143 ounces daily. LMNT is pricier, but I can't stand the taste of the other electrolytes like Liquid IV. GLPs definitely slow down hydration – and the electrolytes help you actually absorb the water. TMI, but I used to just pee everything out immediately. Now I pee less often, but it's more when I do. It's wild.
 
I couldn't resist making a meme out of that.

And I just realized I misread your statement. I think you mean LMNT is amazing, but I thought peeing WITH LMNT was amazing.
 
I bought a big water bottle with measurements on the side. I fill it up in the morning with my Costco electrolytes and try to chug about 120oz a day. It's helped me hit my hydration goals. And the Costco liquid IV electrolytes make the water taste good.
 
I've always had an electrolyte drink with my shot and drank a ton that day. I already drink a gallon a day, luckily I was told to do that from the start. I skipped it twice in 7 months. Never again... my migraines start in my neck, and that triggered them hardcore.
 
Interesting point about vision changes, @FL_Sunshine_77. I saw something about that too. I'll keep that in mind. I'm also thinking about how GLP-1s affect other aspects of health. I read a little blurb about a possible link between these meds and ED, Erectile Disfunction. Apparently older guys with high blood pressure might be at a higher risk. It also said that men who lost LESS weight on these meds were also at higher risk for ED.
 
FunkyDad433 said:
I read a little blurb about a possible link between these meds and ED, Erectile Disfunction. Apparently older guys with high blood pressure might be at a higher risk. It also said that men who lost LESS weight on these meds were also at higher risk for ED.
Click to expand...

Well... that's something else to worry about! Seriously though, thanks for sharing that info.
 
100 percent a hydration issue. Won't get fixed by switching medications. They might also run blood work to see if anything else is out of line that could make side effects worse.
 
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