GLP-1: Long term commitment?

Riley2008

Riley2008

Active member
We all know weight can creep back after stopping these meds. But what about those of us who weren't severely overweight to begin with? People just wanting to drop 15-20 lbs, or athletes using them to get shredded? Will their hunger go crazy after they stop, worse than before they started? Are they looking at a lifetime of maintenance, like many of us are already realizing?
 
Since the data is so clear on weight regain, people should just plan to stay on them indefinitely. It's like trying to use some other experimental drug to maintain the loss – doesn't seem smart. People don't expect to stop taking statins once their cholesterol improves, so why the fuss about GLP-1s?
 
hesitant on oral glp1 until i see long term safety data. sticking with injections for now. that's what i'm comfortable with.
 
If your friends can drop the weight and keep it off with 'normal' methods, great. If not, I don't think the amount they need to lose matters if a GLP-1 is the only thing that works.
 
You can do both, @Riley2008: tell them it works well, and also tell them the risks of stopping, no matter how much they want to lose.
 
Just my 2 cents: Most of the weight loss can be maintained if you make permanent lifestyle changes, like healthy eating and regular exercise. Of course, you'll lose the metabolic advantages, so some weight gain is normal, including inflammation. Just my opinion; I'm not a doctor.
 
I tell people I plan to stay on it forever, same as blood pressure meds. But people are going to do what they want anyway. I know tons of people who get it compounded, lose 15 lbs, then gain it all back when they stop. Weight Watchers has been profiting from this cycle for decades.
 
To me, it's about what percentage of their body weight they need to lose to reach a healthy BMI, any existing health problems, and their age. I'm on tirz for the anti-inflammatory effects more than the weight. I only lost about 35 lbs, but it was a significant portion of my total weight. Going from 6'4" 230 to 200 is much easier than going from 5'2" 120 to 90.
 
Funny, I was just talking about this with my Botox injector. I'm one of those folks who are always close to goal, yoyo-ing, with an extra 15 lbs. I eat a mostly clean diet, but I always gain it back after sema; never more than I started with, though. I'm losing with Reta now and she recommended a maintenance dose when I hit my goal. I prefer to cycle any exogenous compound so my body doesn't become dependent on it. I'll stop when I hit my goal and use an extra vial when I see it coming back.
 
I'm going to lower the dose slowly when I reach my goal weight, just as I slowly increased it. I'm 6 months in and only at 1.9 mg/week, happy with losing 1-2 lbs/week. I plan to come off completely and see what happens. If I gain weight back and it doesn't stabilize, I'll use reta again to get back down and find the lowest maintenance dose. I have to at least try to titrate down to zero to see if it's possible for me.

This is my first GLP experience. I understand why those who have used them before don't want to stop. But I need to know if I can use it as a tool and then move on. If you want to know about cycling, look up “Ayubace” on social media.
 
Veggie said:
I started at 176 and want to be at 125 in March. I won't even TRY to get off once I hit my goal. Why would I? I've tried losing weight multiple times, only to gain it all back. I'm 45, and my personal data tells me I'll just fail without GLP-1s.
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I feel this so hard. It's like, why even risk the regain? It's so freeing to not constantly be fighting my own body!
 
I agree with
Terry55 said:
Since the data is so clear on weight regain, people should just plan to stay on them indefinitely. It's like trying to use some other experimental drug to maintain the loss – doesn't seem smart. People don't expect to stop taking statins once their cholesterol improves, so why the fuss about GLP-1s?
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This is exactly what I've been telling my friends! It's a long-term thing for most of us.
 
It's so nice to be able to travel and not worry about fitting into airplane seats or what clothes to pack. I can actually enjoy my vacation now!
 
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