GLP-1 maintenance - what's working?

LeanWine

LeanWine

Active member
Anyone willing to share their experiences with maintaining weight after loss, plus what's helped or hindered? I'm trying to navigate my next phase after a slight setback. I took a break from peptides in December because of international travel chaos and forgetting to pack everything... huge mistake! I restarted Reta a couple of weeks ago, but haven't fully resumed my regular pep regimen (glow, ss31, etc.).

One unexpected challenge is increased digestive side effects, which I didn't have before. I'm about 10 lbs above my goal weight, so I'm planning to stay on a lower dose (currently 5mg, down from 8mg). I have some tirzepatide, cjc, hgh, and tesa stored, and I'm debating the best path forward for maintenance. Also, has anyone else found that as visceral fat decreases, finding good injection sites gets harder? I can't inject on my flanks at all anymore.
 
Following! I'm also figuring out maintenance. I've lost too much weight and want to regain a little. Should I stop injecting altogether or just use a very low dose? I'm also curious if NAD is contributing to weight loss.
 
I need the glucose control, so I'm trying to maintain through diet instead of adjusting the dose. Before the shortage issues I learned I could space my injections beyond 7 days and still maintain stable glucose. So, my first line of defense is eating more, then spacing out injections. I lost all my weight on 5mg and I am staying there.

I'd suggest sticking with a consistent low dose of your preferred GLP or Amylin analog and avoiding the weight fluctuations so many of us have dealt with. Try to eat like 'normal' people: consume enough calories to maintain your desired weight and take your shot.
 
That's a problem I hope to have... I'm also curious about adding NAD. I've been craving sugar a lot lately, and I'm only 5 lbs from my target. I'm waiting for a NAD order to arrive, hoping it might help curb the cravings.
 
I've observed that gradually easing back into things, rather than making abrupt changes, is often beneficial, particularly when managing side effects. Perhaps continuing with 5mg until your system fully adapts could be helpful? Adequate hydration and electrolyte balance also appear to mitigate those digestive issues.
 
I've found that incorporating a monk fast once a week can be very effective for maintenance with a GLP-1. Some people might complain about it, but if the Reta is controlling your appetite, a 36-hour fast, followed by eating near maintenance calories the rest of the week, lets you enjoy food and maintain or even lose a little more fat.

After the holidays, I used CHC/ipa at a low dose, no Reta, and a monk fast every Monday to drop my body fat from 14% to 7%. It was surprisingly easy. I ate very well the rest of the week on a carnivore diet.
 
VialUpdate said:
Following! I'm also figuring out maintenance. I've lost too much weight and want to regain a little. Should I stop injecting altogether or just use a very low dose? I'm also curious if NAD is contributing to weight loss.
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I'm wondering the same thing. I'm thinking of trying to dial back the peps VERY slowly and see if I can hold steady. It's scary to think of gaining anything back!
 
Health_Great529 said:
I need the glucose control, so I'm trying to maintain through diet instead of adjusting the dose.
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That's definitely a smart approach for many patients. Monitoring A1C levels remains crucial for adequate diabetes management during maintenance.
 
I'm worried about going off completely... I saw a post where someone said they started at 247 pounds in October and now is 180 and satisfied! But they also said they need to stay on a maintenance dose because their A1C isn't low enough. That sounds like a good plan. Small dose of medication to help keep blood sugar under control and weight stable.
 
I saw someone else saying they lost 100 pounds since January and is paying out of pocket for 5mg. They were looking for advice on spacing out doses. I would suggest exploring splitting doses if you are comfortable. Some people inject the pen into a sterile vial and use insulin syringes to measure individual doses. A 15mg pen might cost the same as a 5mg but last three times as long.
 
On the same tirzepatide path - been at 5mg over a year and hit my goal. Started adding semaglutide up to 0.4 but not getting that appetite suppression kick. Trying a midweek sema jab tomorrow to bump it. Have a couple backup kits of 5mg sema in the freezer just in case, plus cagri and cagrisema for experimenting once I'm maintaining.
 
usually see 10 or 50mg vials of 5-Amino. 5mg daily. i split 2.5 morning and 2.5 evening. only buy 50mg kits—10 and 5mg require tons of supplies for 20-day cycle. 50mg vials only need 2 reconstitutions, freeze rest for later.
 
felt appetite suppression right away on even the lowest dose. lost fat in the first month but might've been boosted by quitting alcohol. just finished my first month and now I'm hungry the last few days before my next shot. thinking about upping the dose but not sure about doubling. you exercise?
 
Wasn't sure if you'd seen or tried higher max doses. My 2mg Epi felt like a middle ground between the 5-10mg crowd and the micro-dose crowd. Couldn't find bad effects at higher doses so figured I'd stretch one vial out.
 
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