I went on GLP-1s for stage IV endometriosis, the inflammation was insane. After my 4th surgery I kept gaining and nothing helped. A year in I'm down just 14 lbs, with 15 to go. I eat as before but have a bit more dietary freedom, and I train as before but now I actually see changes. Best win: much less painful bloating. I've set myself up for success now. The side effects do exist, yet I'm feeling the best in years.