GLP-1 weight regain - inevitable?

I realized this when I was losing a pound a day just by fasting. Zero exercise. 21 days without food. That was last fall. I've been on a journey since then to unlearn everything I was told about diet and exercise. Only *I* control what I become. No one else is responsible for what I put in or get out of my body.

Your mileage may vary.
 
Agreed 1000%! It's a big difference. My spouse and I are both on GLP1s, but we approach it differently. We've lost the same amount of weight, but I use a body comp scale daily to track fat % loss vs lean/muscle gain %.

I'm working out every day and seeing about an 8% loss in fat mass and a 7ish% gain in lean/muscle. She's losing both equally.

Same weight loss, but huge difference in body composition!
 
It's basically yo-yo dieting. I've seen my mom lose and regain weight so many times. For some, the temptation of junk food is just too strong. Whether they lose weight with willpower alone, or with GLP-1s, the willpower eventually fades, or they come off the meds, and it all falls apart.

I'm starting to think genetics play a big role in appetite. Some people are just born with a lower appetite and feel full faster. Maybe GLP-1s are just evening the playing field.
 
Yes, my eating changed. The food 'off' switch broke again. Exercise stayed the same: swimming over 6 miles a week, hiking 1000-foot climbs once or twice a week, plus cycling and weights. My calorie intake went way up.
 
My goal is to build better habits so I don't go crazy when I take breaks from the meds. Your idea about length of time on the meds might be right. Maybe you have created better habits.
 
The people who regain the weight and then some always say they're constantly hungry after starving themselves to their goal weight.

I've been lowering my doses so I actually feel hunger. I want to feel genuine hunger throughout the day, and not struggle to eat enough.
 
I'd be one of those people if I stopped taking them. I've learned to handle being hungry and not feeling super 'full' after meals. I've always been active and love the gym. It's all about the food noise. I get genuinely hungry now, but it's so freeing not needing to eat immediately. I can finish what I'm doing, and sometimes even forget about it for a while. I spent decades with food constantly on my mind, and I'm not going back. These drugs weren't available then. I use tirz because it was better for the food noise than sema. If there's ever an API that just targets food noise, I'll probably take that. But tirz is working great, and I have a bunch in my freezer.
 
What's so bad about taking something for life that lowers your risk of heart attacks, strokes, and dementia? People take vitamins hoping for a fraction of the benefit of a GLP-1.
 
And what about the food noise? My spouse realized what 'normal' people's relationship with food is like. She struggled with that constant background noise, even when she was successful. Reducing that mental load, plus all the other benefits? No reason for someone like her to stop taking at least a minimum dose!
 
This is so important. Bias in = biased results out.

Also: how did they stop the medication? Every FDA study I've seen stops at the therapeutic dose to zero. (Therapeutic doesn't mean the highest dose.)

If a doctor stopped an SSRI the same way, it would be malpractice.

Maybe some people can stop, and some can't, like with SSRIs.
 
I read on Reddit about a guy who stopped Mounjaro because he lost his motivation to exercise and eat properly. He was losing muscle because the appetite suppression was too strong. He quit for a month, started lifting and running, and felt much better even though his weight was the same. Said he felt stronger and more alive.

He realized he needed to find a way to work out *while* on Mounjaro. If you are just trying to lose weight, you probably don't care, but if you want to keep the weight off and build muscle, you have to do both fitness and diet.
 
It seems like a lot of people are tapering off Wegovy now that they have reached their goal. One person said they were down 95 lbs and planning to be off by summer and, more importantly not gain it back. That's my plan too. Slow and steady wins the race!
 
I think I'm going to try a really low dose when I get to my goal weight. Like someone said, maybe just enough to take the edge off without killing my motivation. I'm gonna try to keep lifting weights as non-negotiable, no matter what.
 
These drugs just cut appetite, they don't magically drop weight. You still choose whether to eat less and create a deficit. If it's not working for appetite then you might be in that ten to fifteen percent of people these don't suppress hunger for.
 
Drop significant weight and fertility improves. Less body fat means less estrogen floating around, so the ovaries get back to business. Plus the medication helps everything else run better too.
 
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