GLP-1s and inflammation?

Chill_Chick151

Chill_Chick151

Member
I've read that obesity causes constant, mild inflammation because of fat tissue releasing inflammatory stuff... But I've also heard people say they lose water and "inflammation" on these meds. How do you even tell? Is that just a feeling or is there a way to measure it? Thanks!
 
Inflammation makes you retain water. When it decreases, you drop the extra fluid and look less puffy. I think that's one of the first things that happens on these meds...you might not see a huge weight change right away, but your face and hands look different. I didn't realize how inflamed I was before!
 
It's not super scientific, but you can just 'feel' less inflamed. You have more energy, you move easier, and your brain even works better. For me, I noticed I felt more rested when I woke up even if I didn't sleep any more than usual. So, yeah, no specific number, but a noticeable improvement in how I felt.
 
I have rheumatoid arthritis and a history of ulcerative colitis and Crohn’s. I was taking a biologic for the joint pain, and it helped some, but not completely. Now that I'm on this medication, the remaining joint discomfort is totally gone. My inflammation levels in my bloodwork are also lower.
 
I get blood tests every three months that include inflammation markers because of another medication I take. Before this med, my inflammation was high. Now it's in the normal range.
 
I have endometriosis, insulin resistance, and a really bad histamine intolerance with heart racing and breathing issues. My blood work always showed high inflammation (CRP over 2.5). All of that is better since I've lost weight and started Mounjaro. My blood work improved, and my symptoms are better. After six years of a super restricted diet, I can eat some foods again! Eating a little chocolate or cheese without a reaction is amazing. My old doctor suggested Saxenda for my endo and histamine issues, but it was too expensive at the time. Ozempic gave me side effects, but Mounjaro has been great. https://pubmed.ncbi.nlm.nih.gov/41032183/ I'm not a super-fast loser like some people (only 20kg in a year), and I was already somewhat active before (hiking weekly, swimming in summer), but I'm losing weight consistently and building muscle (weightlifting twice a week, cardio once, hiking once). This has really changed my life.
 
I lost a lot of puffiness after a couple of shots, and my brain fog cleared up fast. A rash disappeared, and I stopped wheezing. But my CRP, an inflammation marker, actually went up. I'm not sure how many people get bloodwork to confirm the anti-inflammatory benefits. I bet it's not many.
 
I had awful knee pain and was scared I'd be disabled soon (at 39!). The doctor said my knees were fine, suggested collagen, but it didn't help. A few days after my first shot, the pain vanished (before any weight loss). It was like a miracle. I can squat, sit, stand, run – no pain. It's been six months, and I'm so thankful.
 
I used to wake up feeling stiff and achy, but that's gone now. Obesity can cause fatty liver, which then causes inflammation.
 
This year (a year and a half on this med), my ESR and CRP were normal for the first time in over ten years. I don't think my inflammation was just from being overweight, since I was only slightly overweight for part of that time, but this med worked anyway. The bloodwork confirms it, but I also just feel better – less pain, less achy, less heavy – even before the weight really started coming off.
 
It’s not just an opinion, it’s true. My hip pain disappeared three months in and hasn’t come back. That was 9 months ago. And my bloodwork is also improving.
 
I saw someone on Reddit say they got off their blood pressure meds after starting Ozempic. Anyone else have that experience?
 
I was just reading a post where someone said their cholesterol and triglycerides are finally in a good range after a year on sema. It's more than just weight loss, I think!
 
Drew1984 said:
I saw someone on Reddit say they got off their blood pressure meds after starting Ozempic. Anyone else have that experience?
Click to expand...
It's likely from the weight loss reducing the workload on the heart. Less mass to pump blood through.
 
I've heard a lot of people mention improvements in blood pressure. Weight loss definitely helps, but it's interesting to think there might be other mechanisms at play too.
 
Liver fat and inflammation track together - both follow the insulin resistance improvement, usually within months 3-4.
 
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