GLP-1s crossing into the brain?

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Whole_Free783

Active member
I hadn't realized semaglutide (and I guess the other GLP1 mimetics) were known to get past the blood brain barrier.









The one, big unanswered question about Ozempic

Millions more people will be taking a GLP-1 soon. What’s the catch?




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Explains a lot, re: the "food thoughts" quieting down. I just assumed my gut was doing all the work.
 
Great article, thank you so much for sharing. It helps me understand that even though I haven't been very hungry at all since last autumn, and I also haven't had any cravings in months, I can still enjoy eating when I do.

I also stopped biting my nails, which is amazing. I enjoy browsing online shops, but I don't spend anywhere near what I used to. The positive health changes are fantastic, but these other victories make me think I will keep taking the drug at a low dose even when I don't need it for weight control anymore.
 
When you consider the challenges many of us faced before these medications, and the likelihood of a reduced lifespan for some, some of these concerns seem minor. Plus, the long-term cost savings would be substantial, so the government should be giving these out like candy.
 
ThePal said:
@FiberWine I've heard of BPC-157 but don't know much about it. What kind of healing are we talking about?
Click to expand...

Things like muscle tears, tendon repair, even some organ protection effects in animal studies. There's also some limited human data suggesting it can help with stomach ulcers.
 
Speaking of costs, did you all see that Novo Nordisk is supposedly cutting prices on Wegovy and Ozempic? I read about it on Reddit:

Of course, there's a catch... the cuts aren't until 2027 and require insurance. Still, it's a step in the right direction.
 
Legally speaking, hiding medical substance use from doctors puts someone at real risk if complications happen. I can't stomach the idea of getting someone into a risky situation then staying silent about it. The law issue worries me less than the human cost. Thing is, at 77 with that history, even the best peptide can only do so much without lifestyle changes over months or years.
 
Mad at myself for the trap. Add so I struggle waking up. Thought my brain was glitching. Rushed, hadn't planned to log in but had items to share before my schedule. No time to deal with forum restrictions to make a topic, already behind.
 
You're essentially fighting your own system. Remove carbs your body runs on daily and it needs days to adapt. Then layer a false GLP signal tricking your brain into thinking you just ate, so it assumes carbs are heading in. Can't absorb carbs that never arrive. Your body kicks out extra insulin for imaginary carbs. Don't act surprised when it pushes back.
 
University team from Colorado Boulder plus Stanford plus Baylor isolated python blood molecule: crosses into brain, kills hunger without the side issues limiting other weight-loss drugs.
 
Anhedonia on GLP-1s has been my main thing to work through. With the oral version it goes through the liver first. That might mean the sides are softer? Would that extra pass make it harder to cross into the brain space? Love to hear from anyone who tried both types.
 
Oral sema's first-pass effect does reduce bioavailability significantly - roughly 70-80% is metabolized before reaching systemic circulation, which likely dampens both the GI side effect profile and CNS penetration. The anhedonia question specifically is whether the BBB crossing that produces the dopamine circuit effect scales with plasma levels or depends on some other delivery factor, which isn't fully characterized yet.
 
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