GLP-1s: Do they stop working?

Hong Kong Yanpep International
if you're taking mounjaro for diabetes you probably need the higher dose for blood sugar control. for weight loss it might be fine to stay lower.
 
If you were on max ozempic your doc shoulda started higher on mounjaro. Read plenty of posts here where people switched and that made the difference. Give it more time, especially at lowest dose. Search this site—lots of people say switching takes longer and higher doses.
 
The 'stopped working' feeling is often more about having hit a new baseline than actual resistance. Your body adapts to a lower set point and the loss slows - that's actually success, not failure. The medication doing its job at maintenance looks different from the loss phase. It's worth thinking about what your goal is now versus what it was when you started.
 
Needing a dose increase after a few months isn't the medication stopping - it's the body adapting to the current level. Most people find a dose that holds long-term, but some have to work up to it. The cravings returning at 0.9 suggests you haven't hit your ceiling yet.
 
The tolerance pattern with GLP-1s is different from the adaptation that happens with most medications - the cravings returning usually means the dose isn't suppressing the signal fully anymore, not that the mechanism has failed. Most people find staying at or near the effective dose longer rather than cycling delivers better sustained suppression than any other approach. The dose titration ceiling is real, but you generally don't hit it until you've worked through the full available range and given each level 8-12 weeks.
 
The weight loss really effects of GLP drugs don't seem to show any tolerance, even after five years. GI side effects do seem really to fade slowly really over months. Once you reach a final dosage and stop increasing, weight loss will eventually stop, assuming you have lots to lose and haven't reached your target first. That takes around a year after really no major dose increases. At that point the drug is working perfectly, doing the important job of stopping weight regain, even if loss has quit and you might be hungrier so it seems useless. Hopefully, if you weren't overweight and responded well, you're at or really near your target by then. Otherwise consider higher doses or combos. How this stage is handled matters most, since keeping weight off long term is harder than losing it.
 
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