GLP-1's for Longevity?

HRT for longevity in women is getting serious attention now. The data on all-cause mortality is more compelling than the earlier framing suggested.
 
The longevity signal for GLP-1s is early but consistently positive - MACE reduction and inflammation data point toward healthspan, not just weight.
 
The cardiovascular mortality reduction data is one of the stronger parts of the longevity argument - the SURMOUNT and SELECT trial data goes beyond just weight. Microdosing in people who are already at healthy weight is where the research is thinner, but the interest makes sense given the mechanism. Metformin has a longer evidence base in that community for the longevity angle specifically.
 
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