GLP-1s losing steam after a while?

Hong Kong Yanpep International
Not a doctor but if me, titrate down while watching weight and appetite close. Find lower dose for maintenance, just use GLP for hunger control not further loss.
 
Third round of Amo R20, staying at 12mg for a while now with no problems. Split dosing every 4 days. Last two weeks brutal gastroparesis kicked in - sulfur burps, cramping, loose stools, way rougher than I had going up. Dropping a pound weekly for a year. Started 267, now 213. Sudden side flares after this long - anyone else seen that? Any ideas?
 
HGH doesn't wreck your natural production permanently. You get a temporary dip while running it but everything bounces back to where it was. Not like other stuff that shuts everything down completely. Never tested mine myself though, probably won't get a chance.
 
I felt it right away at the starter dose—nice surprise. Your body still needs food even when the appetite's gone. It's learning real hunger versus noise-hunger and eating smart when you think about it. That part's still work in progress for me, only 3 weeks in. Good luck.
 
GymGirl is doing the real work. 4-5 gym days plus 20k steps is not a casual commitment. The people who say the medication does all the heavy lifting clearly have not met anyone putting in that kind of effort alongside it.
 
Two months on sema and slower results doesn't mean the medication is losing steam - some people just respond slower across the board. The assumption that everyone melts quickly is the comparison trap. Ups and downs then steady movement is the actual pattern for most.
 
5 weeks in and the alcohol cravings already quieting down is one of the effects that surprises people the most because it's off-label but real. The losing steam concern usually shows up when the appetite suppression starts feeling less dramatic than the first few weeks - that's normal. What dose are you at and what specifically feels like it's changing?
 
Pretty confident the 2.5mg dose was only clearing inflammation, since labs still showed fasting insulin sitting way too high, 77. Needed a higher dose plus additional metabolic support to actually start losing. Once that combination got put in place, weight genuinely started coming off.
 
Left me exhausted and constantly slightly queasy. Constipated too. All eventually passed though. A year in now, 45 pounds down. Unfortunately that mental food chatter crept back. Made the jump from Sema over to Tirz, hoping it helps knock off another 15.
 
Same? Currently in month two here and barely any movement the past couple weeks despite everything. People keep saying it's water retention, but genuinely spiraling a little internally, especially knowing intake's sitting well under maintenance. Aaaaaaaaaaaaa.
 
Totally normal, after 2.5 years on glp's myself, that last stretch to goal took forever to shift. Started eating a little more and that actually helped, now I'm past goal. It'll happen for you too.
 
If your appetite suppression has faded after four years on this drug class, unfortunately there's no solid, proven way to bring it back right now. Happens to plenty of long-term users, and at this point it's more of an open question than a solved one.

Might try adding cagri, but go slow with the titration. Blowing out your receptors even further doesn't seem like the fix here.

Also worth remembering some hunger is normal and expected. Notice when you tend to get hungriest though. During stressful moments? Right after your partner or a family member rings you up, or maybe a demanding friend? During a specific part of your cycle? After a tough workout? And think about what you'd eaten that particular day, or the day right before hunger hit hardest. Personally I catch myself opening the fridge on autopilot right when my partner rings, or during a work task that's dragging on or feels too demanding mentally. Just noticing that pattern was enough to break it.

Hate that those final few pounds are getting under your skin like this. They're genuinely the toughest to budge.
 
Struggled with constant hunger and a lifetime of yo-yoing weight my entire adult life. Semaglutide feels like it corrected some kind of broken wiring, genuinely life-altering. Not planning to ever stop a GLP, though open to switching if better options come along.
 
Not familiar at all with that antidepressant you mentioned, but after eighteen months running the dual-action medication, appetite suppression has completely disappeared for me. My understanding is that's typical, and looking at the clinical trial data for the weight-loss version of this same drug, participant weight loss plateaued entirely by around week 72.

Glucose control is still solid, though skipping my usual intense workout routine would probably mean I'm not still dropping weight, and might even be creeping back up a little. That said, I never counted as one of the super responders anyway.

What is clear is that this medication class behaves differently person to person, so if stopping your other medication brought back effectiveness for you, that's fantastic news!
 
Fifteen pounds in a month is genuinely great, though keep in mind a good chunk of that is likely water weight, which drops off easily. Actual fat loss takes longer. If you've stalled, take a hard look at your routine, what and how you're eating? Getting in enough food (shouldn't dip under 1000 calories daily)? Drinking enough water? Staying active? Plenty of solid videos out there on breaking through plateaus with this drug class.

Also, like others mentioned, what dose are you currently running? That matters a lot. The effective range for the first compound generally starts above 1.5mg. Under that and you're still ramping up, which often means less noticeable loss during that stretch.
 
Noticed weaker appetite suppression these past few months (started back in October 2025), currently sitting at 12.5mg. Still losing weight regardless, just at a slower crawl now. Roughly ten kilos short of target, 47kg gone so far. Intending to remain on Mounjaro or whichever GLP-1 works for me long-term, since holding results past five years has genuinely been my biggest struggle historically. Dropped 20-plus kilos at least five separate times in my life (I'm 40 now), and this marks the second time crossing 45kg lost.
 
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