GLP-1's making food...unappealing?

L

LabCrew

Member
I constantly hear that eventually, Tirzepatide floods your receptors and stops working. I haven't found studies about this, but it's a common idea in a lot of talks. However, my family is seeing the reverse. My mom and daughter (30) are needing to lower our doses after almost a year. I keep getting close to food aversions. I was taking 12mg at my highest, now at 6.5mg. I was so tired of eating! Food tastes bad, which is really weird! I stayed at a steady blood level for about five months. Using an injector pen, I sometimes dosed every other day, trying to stay consistent. My daughter, who's a very active teacher, would usually have a protein shake in the morning, a protein bar at lunch and a dinner with protein, veggies, and some dessert. Even though she didn't keep a steady blood level, she also has food aversions, trouble eating, and says food tastes 'off'. She is having a hard time eating. Em was only at 2.5 and has dropped around 40 pounds. It's been a month since her last dose and her appetite is still suppressed. I've lost over 60 pounds, want to lose 25 more or not... Anyone else?
 
I think how well these meds work depends on your own body (like if you're diabetic or not; diabetics usually lose weight more slowly than non-diabetics) but also other things people don't think about: activity level, diet, protein intake, etc. These meds can be a great help, but I think lifestyle changes combined with them can do a lot. I've found that I do well on low doses and still lose a good amount of weight.

Also, other health problems besides diabetes, like PCOS, thyroid problems, taking other drugs (like SGLT-2 inhibitors for diabetes), can change how well these drugs work for you.
 
I agree, thanks. Hopefully, if anyone else has had this experience, they'll share it. I've been worried about 'flooding the receptors' for a year, but it seems to have worked the opposite way. Life is strange.
 
I'm so jealous! I was hoping for that, but I've been going up through the doses quickly. I felt the best at 7.5mg for a few months, but it wore off and I went up again, I haven't felt it since. I lose 1lb/week sometimes and nothing other times.

I think I'll max out soon and then try 'resetting my receptors'.
 
I don't know how you feel about stacking, but adding a milligram or two of a glucagon agonist could help you break through your stall. It might be something to look into.
 
It's fascinating how differently people respond to these medications. Factors like genetics, diet, activity level, and even gut microbiome composition can all play a significant role in individual outcomes. We're only beginning to understand the complex interplay of these variables.
 
I've been losing weight, and the neighbor told me that I was 'cheating' by using weight loss meds, like it wasn't earned. It's frustrating. I wish they knew how hard it still is. People seem to think we just magically lose weight, but that's not how it works. It's still hard work.

Has anyone else had that experience? I'm thinking of saying that it's for my diabetes from now on.
 
I totally agree with LabCrew about people thinking it's 'cheating'.
LabCrew said:
I've been losing weight, and the neighbor told me that I was 'cheating' by using weight loss meds, like it wasn't earned...
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Like, are we in some weight loss competition I didn't know about? People don't realize meds are just another tool. Like glasses for your eyes. It helps you see better, but you still have to actually *look* at things. I've just stopped talking about the medications with people. It's not worth the hassle.
 
I get the 'cheating' comments too. I'm thinking of telling people “Damn right, I’m cheating myself out of an early death.”

It's a tool, not magic. I still track everything and exercise. I wish there were cheat codes for life!
 
I understand what you mean about food tasting funny, LabCrew. I sometimes get these weird metallic tastes after my shot. Does that happen to you or your daughter?
 
The idea of 'flooding' receptors is an oversimplification. It's more accurate to think of the body adapting to the medication over time, which can lead to decreased sensitivity. This is why dose adjustments are often necessary. Individual responses vary widely due to complex biological factors.
 
Year on semaglutide, 90 pounds down. Less food noise, more workouts, easier to stay active. This is only the start.
 
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