GLP-1s making me numb?

Hong Kong Yanpep International
SunnyGrind212

SunnyGrind212

Active member
I've been on 1mg for about a month and a half now. Appetite's gone, and I've dropped about 22 pounds, which is great. But the lack of energy and feeling like I can't enjoy anything is really getting to me. I was super anxious at first, but that's calmed down. Now I just feel...blah. I'm traveling in an amazing place, and even a beautiful sunset doesn't do it for me. Don't even want to go grab dinner. When I feel anything, it's just a heavy feeling of being alone and sad.

I've dealt with depression before but was doing great when I started. This feels different. I want to feel things again! Thinking of stopping cold turkey, but wondering if splitting the dose might help? I need to do something; this isn't how I want to live.
 
SunnyGrind212 said:
I am traveling in an amazing place, and even a beautiful sunset doesn't do it for me. When I feel anything, it's just a heavy feeling of being alone and sad.
Click to expand...

Just checking - are you sure it's the meds and not just regular depression kicking in?
 
It took me almost two full months to start feeling like myself again. The emotional blunting gradually faded, and I feel completely normal now.
 
I read that these meds mess with your dopamine system, which is why they're good for curbing cravings and addictions, but also why you might feel less pleasure. Hopefully, things will balance out over time. Don't give up!
 
I'm finally starting to feel like myself again after the WORST mental health crash ever, and it was definitely from my GLP-1. For about 5 days, I felt totally disconnected from my body with insane anxiety. Then I had two panic attacks without even realizing what was happening until I tried to sleep. The next 5 days, I was so dizzy I could barely see. I'm still not 100%, but I'm getting there. Never touching these things again!
 
Thanks everyone for the replies. I'm definitely going to talk to my doctor about vitamin levels and maybe splitting the dose. n-of-1 I appreciate the thought, but I really think this is different from my usual depression. It's like a wall between me and any emotion.
 
I can totally relate, SunnyGrind212. I've only lost about 10 pounds in two months, but I feel so discouraged. I'm only on a low dose (.25). What dose are others on who have seen better results?
 
It's great that people are seeing results, but remember that everyone's body is different. Focus on the health benefits and consistent habits. Don't get discouraged by comparing yourself to others.
Robin44 said:
I've only lost about 10 pounds in two months, but I feel so discouraged. I'm only on a low dose (.25). What dose are others on who have seen better results?
Click to expand...
Talk to your doctor and see about titrating up.
 
I think it is really hard to notice differences sometimes. I lost a bunch of weight and still felt like I looked the same gross way. I guess it's a mental game too. Good luck to you!
 
Felt the exact same thing at 7.5mg — emotional flatness, music didn't hit the same, social stuff felt like going through motions. Talked to my doc, dropped back to 5mg, and the baseline came back within about 2 weeks. Lost a little less weight per month at the lower dose but it was worth it. Worth flagging for your prescriber if it persists.
 
Fatigue and anhedonia on the active loss doses and then dramatically better at 1mg/week maintenance is useful context for the OP who's 22 lbs in at 1mg and already feeling the flatness. The question is whether the numbing is dose-dependent - if the therapeutic dose is producing the feeling, a slight pullback sometimes resolves it without stopping entirely. How long did it take before you noticed the improvement at the lower dose?
 
Anhedonia on GLP-1s is a known and documented effect - the same dopamine pathway suppression that quiets food reward also affects other reward processing. Some people see it resolve after a few weeks, others don't. Worth bringing up with whoever prescribes it since dose reduction sometimes helps.
 
The low motivation and flat affect on GLP-1s showing up separately from the appetite suppression is documented enough to be real, even if it's not the majority experience. 1mg for a month and a half at 22 lbs is impressive early movement - the question is whether the flatness is a side effect to manage or a dealbreaker. Worth flagging to whoever is monitoring the protocol. Did you notice it more at certain doses than others?
 
The third-dose point is often when cumulative half-life buildup catches up - sustained serum level at that point is higher than the first two doses because each one adds without full clearance. The dry mouth, fatigue, and brain fog cluster is the dehydration component; electrolytes tend to help more than water alone at that stage.
 
You must log in or register to reply here.
Back
Top