GLP-1s: Study Share

Thanks for posting that, lots of useful stuff. It looks like Reta is in the pole position, and the stacking strategies look interesting. Thanks for the dose info too.
 
Thanks for posting! It's super useful and I'm glad I took the time to read it.

It's cool to see the research is really diving into the obesity crisis and new, better treatments are coming. Retatrutide looks especially promising as it goes further into trials.
 
A bunch of reputable hospitals, research centers and companies are working on Retatrutide. Just listing a few:

1. Eli Lilly: They are producing retatrutide and running pretty much all the trials. They plan/run phase 2 and 3 trials like the TRIUMPH series. https://investor.lilly.com/news-rel...trutide-results-published-new-england-journal https://www.verywellhealth.com/lilly-retatrutide-obesity-medication-could-treat

2. Yale School of Medicine: Dr. Ania Jastreboff, who specializes in endocrinology and metabolism, is a major researcher in the Retatrutide studies. Her work is all about treating obesity and finding new ways to treat this. https://investor.lilly.com/news-rel...trutide-results-published-new-england-journal.

3. University of Washington Diabetes Institute: Dr. Subbulaxmi Trikudanathan is looking at how retatrutide affects type 2 diabetes and related metabolic conditions.https://www.verywellhealth.com/lill...-medication-could-treat-liver-disease-7560270.

4. Multiple trial locations in the US: Phase 2 trials were in many locations across the US. These include academic medical facilities as well as research centers. https://www.hcplive.com/view/retatr...ing-glycemic-control-benefits-in-phase-2-data.

These institutions are very important in the research and help see how retatrutide can be used for obesity, diabetes, and other issues.
 
My relative just getting started on their weightloss and I've resisted the urge to either load up on their current drug or get something new to test out next. What they are using now is doing the job. So there's really no reason to change it.

When they hit a plateau after increasing their dose (if that happens) it could easily be that something even better has come out and those extras are no longer needed.

This summary is from mid August 2024. There is a lot happening. Will many prove to be worthwhile? Who knows.

P.S. This is only for a selected group of receptors so that's why a certain drug is not on the list.
 
Yes, they've done quite a few studies on Mazdutide looking at how well it works and if it's safe for treating obesity and type 2 diabetes. Here are some of the main ones:

1. DREAMS-1 Phase 3 Study

This study looked at Mazdutide in Chinese people with type 2 diabetes. The results showed it really helped lower HbA1c (a blood glucose marker) and body weight. After roughly half a year, HbA1c dropped 1.57% in the 4 mg group and 2.15% in the 6 mg group, but only 0.14% in the placebo group. These effects remained constant until around week 48. https://www.pharmabiz.com/NewsDetails.aspx?Aid=171434&sid=2.

2. GLORY-1 Phase 3 Study

The first phase 3 study to look at a GLP-1R/GCGR agonist for weight loss, and showed great results. People on Mazdutide dropped an average of 14.3% of their starting weight after nearly a year. Also, Mazdutide cut liver fat by 80.2% in people with high starting liver fat. The study also saw big improvements in a few heart-related risk factors, like blood pressure, triglycerides, total cholesterol and LDL-C. It seemed to work well and was safe for weight loss and improving metabolic health https://www.biospace.com/innovent-p...t-at-the-the-ada-s-s-84th-scientific-sessions https://www.gurufocus.com/news/2465480/innov

3. Safety profile

Mazdutide was tested at 4 mg and 6 mg doses. It seemed safe, with no new major issues. The most common issues were gastrointestinal, like feeling sick, diarrhea and vomiting, and most were mild. No serious hypoglycemic events were reported. https://www.pharmabiz.com/NewsDetails.aspx?Aid=171434&sid=2.

4. Results

Mazdutide shows good results for type 2 diabetes and obesity by working on glucagon and GLP-1 receptors. Studies show that Mazdutide may be a good choice for weight loss, blood sugar control, and lowering liver fat and other metabolic risks.

For more, visit:

https://www.clinicaltrialsarena.com

https://www.biospace.com

https://www.pharmabiz.com
 
Wow, resisting the urge to experiment with everything and stack every drug in every way possible... just because what you're doing is working? Who are you?! 😉😁❤️
 
Right now, there aren't any trials specifically looking at combining Retatrutide and Cagritutide. But, its helpful to know how the combo could work since they affect similar processes.

Retatrutide and Cagritutide:

1. Retatrutide is a "triple agonist" affecting GIP, GLP-1 and glucagon receptors. It's meant to cut weight, manage blood sugar, and ramp up energy use. It has shown promising weight loss and cardiometabolic results. https://www.nature.com/articles/s41591-023-02538-7.pdf https://link.springer.com/article/10.1007/s00228-024-03646-0.

2. Cagritutide is a GLP-1/GIP agonist. It aims to boost GLP-1 action. It is supposed to reduce hunger and improve insulin sensitivity. Because they both use GLP-1 receptors, combining them might be beneficial for managing weight and metabolic profile.

Benefits of combining

Retatrutide might offer fat loss and higher energy burn via its glucagon action, while cagritide further suppresses appetite and improves insulin sensitivity by enhancing GLP-1 and GIP. There are no trials specifically studying this combo, further research would be needed to see how safe and effective it might be.

Final thoughts

While there are no studies on this combo, existing research hints at possible benefits when co-administering drugs that do similar things. More research is necessary to understand the efficacy and safety of the combination.
 
I'm not sure where this person is getting their information, but it's like ChatGPT's less-developed sibling. Cagritutide is not a thing.
 
That last post is just completely wrong, which is why you shouldn't use AI for real information.

1) It's Cargrilintide.
2) Cagrilintide isn't a thing by itself, its combined with semaglutide
 
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