Help with Sema Dosage - Am I Doing This Right?

Snack-Progress

Well-known member
Okay, I'm really trying to get this down! Could someone double-check my thinking on semaglutide dosages? I feel silly asking, but I'm nervous about getting it wrong.

I received a sample of sema, which is a 5mg vial, and was told to start with a 0.02mg (that's 20 units on my syringe) injection. I then got a 6.77mg vial. Does the 6.77mg mean it's a stronger concentration, or just that there's more total? Should I still inject 0.02mg with the 6.77mg?

I'm so thankful for any help! You folks are the best.
 
Whoa, hold on a sec. There are a couple things to figure out first. You need the peptide mg in the vial AND the amount of bacteriostatic water you're using.

SlowNSteady68 shared a calculator that's super helpful.

Definitely read the guide in my signature (it's got some good info!), and maybe watch a quick YouTube video or two.
 
I'm assuming you meant 0.2 mg, not 0.02 mg -- 0.02mg would be an extremely small sema dose. The amount of sema in the vial and the dosage you want are two different things.

The tricky part is diluting the sema with bacteriostatic water, and deciding how much water to add. Once you have all these values, you can figure out the correct amount to draw into a syringe.

Arithmetic is your friend! It looks complicated at first, but I suggest you research the process so you can verify the calculator's results. A calculator is a tool, not a substitute for understanding. Blindly trusting it can lead to errors.

Here's my approach:

First, calculate the mg per mL of the vial. This is the concentration.

For instance, if you add 2 mL of bacteriostatic water to a 5 mg vial, the concentration is 2.5 mg/mL. This vial would contain 25 doses of 0.2 mg (5 mg / 0.2 mg/dose).

Next, figure out the syringe volume:

Divide the desired DOSE (in mg) by the VIAL concentration (in mg/mL).

0.2 mg / 2.5 mg/mL = 0.08 mL

To verify, 0.08 mL is 1/25th of 2 mL, which is correct since the vial has 25 doses of 0.2 mg.

Finally, convert mL to units. One unit equals 1/100 mL. Syringes use units for easier readings. So, 0.08 mL * 100 = 8 units. Don't mix these up!

Run these calculations with your specific values.

Also, consider the amount in the vial. Check the CoA -- you have one, right? Use the average weight as the true amount. For example, if a 10 mL vial tests at 11.4, 11.3, and 11.4 mg, the average is 11.4 mg.

Last, check that the syringe volume is reasonable. If you're using 100-unit (1 mL) syringes, 8 units will be hard to measure. Smaller syringes (30, 50, or 100 units) have more distinct marks. You can also add more BAC to the vial for a larger shot volume. 2 mL is standard, but you can go up to 2.5 mL. Adjust this amount to make measuring the volume easier.
 
I'm on Mounjaro, and my doctor keeps bumping up my dose. Started at 2.5mg, now I'm at 12.5mg. I've lost about 50lbs since October, but the higher doses don't seem to be working anymore! I've actually gained back about 5lbs and can't seem to control my eating. Anyone else experience this?
 
Dosexo said:
I'm on Mounjaro, and my doctor keeps bumping up my dose. Started at 2.5mg, now I'm at 12.5mg. I've lost about 50lbs since October, but the higher doses don't seem to be working anymore! I've actually gained back about 5lbs and can't seem to control my eating. Anyone else experience this?

Yeah, some doctors are too quick to increase the dose. If you're losing weight and feeling good on a certain dose, there's no need to increase it until you plateau. Some people even go back to a lower dose that worked for them. It might be worth discussing with your doctor.
 
I'm titrating down from 2.4 Wegovy to 1.7. I was on 2.4 for over a year. I'm nervous because I'm starting to feel hungrier, and my weight is creeping up. My doctor warned me this could happen. It's so disheartening seeing the scale go up even a little!
 
ThinLizzie82 said:
I'm titrating down from 2.4 Wegovy to 1.7. I was on 2.4 for over a year. I'm nervous because I'm starting to feel hungrier, and my weight is creeping up. My doctor warned me this could happen. It's so disheartening seeing the scale go up even a little!

That rebound hunger is rough! It sounds like your body is telling you it needs that higher dose. The good thing is you're aware of it and can adjust accordingly with your doctor's guidance.
 
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