Injection Site Reactions - where?!

ISRs and I are good friends now. My first few shots were fine. Now, all my recent injections and most other SubQ injections cause days of redness, bumps, and itching. I'm spacing out my injections more and not starting new cycles until I get this under control. Topicals don't help much, and Zyrtec helps a little but not enough.
 
It might have started after I changed BAC a while ago. The first few weren't too bad, but I'm not sure. I have smaller vials, so if my next BAC is bad, I can try another one soon. It's a good reason to buy small vials; I wouldn't want a big vial if the BAC causes problems.
 
Lucky! Mine are usually fine for a day then the redness, bump, and itching start. I need 4-5 days with no ISR to say it's probably solved. Ice helps a lot, then Zyrtec, and the topicals give a bit of itch relief.
 
I'm waiting for a pH tester to get here. I heard the BAC water's pH could be too high and cause issues. I'm checking the vials to make sure it's not that.
 
I had old pool test strips, so I tried them. Distilled water was neutral, as expected. Filtered water was too. One BAC water tested around 6.2, and the other, the one I had issues with, was around 7.5. Not sure it means anything, but it was interesting.

BAC water isn't too expensive, so I'll probably stop using the one that I know causes problems. If I still have issues, I'm just unlucky. I'm getting another brand soon and will test it when it arrives just to see.

My tap water seems very basic! It should be around 6.5-8.5, but it looked above 8.5! I'm only drinking filtered water from now on.
 
I had my first ISR after mixing my first vial from a supplier on week 8. I panicked and used a brand name I had saved. I got the same ISR, so I went back to the other. I had it for the next six shots. The last two shots have been very minor - almost gone. Yay!
 
MixBro said:
I always injected in my stomach but read that people had better luck pinning in their thighs. Well, that was a big mistake for me. The thigh was the worst!
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I've also heard about people tracking injection sites to see if they reduce side effects. I wonder if there is a sweet spot that helps with nausea vs apetite.
 
I read an article discussing that it doesn't matter if you inject IM or sub-q as long as you are using the correct needle size. It stated that any absorption differences were purely anecdotal.
 
MOTS-C can leave a really angry red spot. Using more diluent helps - I was way too concentrated at first. Cold pack and pressure right after the shot made a big difference for me.
 
Any spot with actual subcutaneous tissue works fine. Though if you get a reaction at the site, sitting on it might be uncomfortable! The stomach is usually easiest unless there's a reason that doesn't work for you.
 
Found it! Opened the pen and the mixed peptide looked cloudy. Made a fresh batch and the reactions stopped. Always mix the vial right before you inject. Got the supply from one source but they've gone quiet.
 
It's a peptide chain that breaks down at the injection site and triggers the system locally. Shouldn't accumulate in your body long term. From what I've read, mild stimulation of that pathway can normalize pretty quick once you stop.
 
Higher doses trigger allergic responses and severe itching at injection sites over 1mg. Subcutaneous causes unbearable redness and itch; intramuscular leads to muscle swelling. No systemic reaction yet but I stay vigilant. At 1mg intramuscular I'm fine. Do not jump to 5-10mg without testing tolerance first - you could face anaphylaxis, which is documented with this medication. Be cautious.
 
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