Just started Oz... is this normal?

F

FiberWine

Well-known member
Hi all.

I (41f, 6' 1", 315lbs) was just prescribed .25mg Ozempic this week and took my first dose 2 nights ago.

My doctor prescribed it for T2 Diabetes. I’m also taking Metformin 2000mg daily, which I’ve been doing for over a year.

For the past 48 hours, I’ve had zero appetite. I feel hunger, but nothing sounds good. I forced down some cereal this morning. It wasn’t great. No sickness, stomach issues, etc. I get how people lose weight if this is what it’s going to be like.

Is this typical, or am I just at the beginning of this journey?
 
Sounds pretty standard, but make sure you're prioritizing protein and fiber. I make a good plant-based protein shake in the mornings with added vitamins, etc. I treat myself sometimes, but what I do eat needs to be packed with nutrients because I'm eating so little.
 
Metformin and Ozempic often go together. It's even being researched for longevity. Prioritize protein and fiber. Focus on eating healthy, and the meds will do their job. I feel the same way – I know I'm hungry, but nothing appeals to me. Often, I just don't eat anything. Then the weight falls off.
 
Sounds normal to me... I started in Sept '25 and didn't notice appetite suppression until I reached 1mg. But since then, it's been great. Reduced my fasting blood sugar from 140-160 to consistently below 90 and lost about 65lbs. I was taking 1700mg metformin and gliclazide but now I am only on 850mg metformin and will likely drop that soon, too.
 
I saw a good tip somewhere: if you want to eat something not so healthy, add something nutritious to it. Like ice cream? Add berries. It's about adding, not taking away!
 
Also, prioritize sleep as much as possible. Sometimes the indigestion and nausea make it difficult but good sleep is critical for hormone regulation and metabolism. If I have a bad night, I have no shame taking a 30-45 minute nap during the day.
 
Curious about your first week loss - did you start at the standard 2.5 or lower? How does this compare to your biggest drops before? I started at 1mg since I react easily, lost close to 2 pounds that first week though it coincided with getting sick and TOM. Interesting thing was the usual morning aches and foot pain improved about 80% even while dealing with the flu. Everyone's path is different but helpful hearing how it went for others.
 
Guy_Fresh said:
Also, prioritize sleep as much as possible. Sometimes the indigestion and nausea make it difficult but good sleep is critical for hormone regulation and metabolism. If I have a bad night, I have no shame taking a 30-45 minute nap during the day.
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Good advice! I find that if I don't sleep well, the side effects are way worse.
 
I did get blood work and it's totally transformed after these meds and shedding 100. All my markers are going down or back to range. A1C was 5.7 and now 5.4.
 
Injection site for Oz is abdomen, thigh, or upper arm per label - rotating within each area prevents the tissue buildup that causes absorption variance over time.
 
240 to 120 (and now 5'7, oddly). Maintenance for years. Hardest part wasn't losing weight—it was food noise. Mounjaro gave me actual satiety cues I think I never had. Worth the $500/month for real.
 
I stuck with established providers like Zappy Health mostly for peace of mind. Going outside normal channels felt risky so I didn't explore other options.
 
Found the answer in another forum thread. She wanted to know about spacing between different retas from different sources. No break needed. Just the normal weekly shot if you go that route.
 
They don't get how this stuff works. You lose weight through work and discipline. The med just stops your body and hormones from fighting you. Obesity comes from chronic messed-up hunger hormones, same way depression is a serotonin imbalance, not a character flaw. This med brings your body in line with how things work in healthy people.
 
how you frame it matters if you care. i just tell people straight up i'm on it. if they want details i explain the whole picture—trt, medication, the stuff that's been affecting my appetite for decades.
 
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