Life changing meds!

Hong Kong Yanpep International
How do you all define goal weight versus ideal weight? I'm 180cm, 104kg now. Ideal says 71kg but that's 33kg down from start and seems huge. Should I aim for a compromise like 80kg or push to ideal? What's realistic?
 
The confidence piece is what most people don't predict going in. The weight change is visible in the mirror but the social change - being able to show up in the moment without the mental overhead - is the part that's harder to anticipate. Threads like this are useful because they show the full picture rather than just the scale numbers. For people on the fence about whether the sides are worth it, reading what actually changes in daily life is often the more persuasive data point.
 
Persistent hunger through the full weekly cycle is the clearest indicator of inadequate dose or medication fit - if it's not quieting by mid-week, the prescriber conversation is appropriate.
 
The 'wanted to but never did' pattern with nausea is more common than people expect - the signal fires but the actual event is rare. When the GI effects go the opposite direction that tends to persist longer into the treatment than the nausea does for most people. The cannabis mention is worth noting - it can interact with both the nausea response and the GI motility in ways that are hard to separate.
 
The few days of constant nausea at the initial 1mg dose followed by it clearing is the most common arc people don't hear about before starting. The OP's waves of nausea getting better and not realizing how heavy they had become is the same before/after recognition from the other side. Once the body adjusts to a dose, most people find the nausea settles unless they go up again.
 
Zofran's mechanism is well-matched to GLP-1 nausea - it works on the serotonin pathway in the GI tract rather than centrally, which is the pathway the medication activates. The prescription requirement makes it an underused option for people who are white-knuckling through dose increases when a few doses of ondansetron would make the difference between continuing and stopping.
 
First week and a half of fatigue plus headaches at shot 5 still is on the longer end of the adjustment window but not unusual. The OP's progression from waves of nausea to mostly better is the arc you're still working through. Doctor's advice that keeping liquids down is the main marker is the right triage - if you're there, the rest can be managed.
 
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