Mazdutide: Anyone seen results from phase 2?

[BoutiqueCompounding]

It appears quite encouraging... Has it become available from suppliers yet?

 

[WildLife]

Yeah, I think I've come across it here and there.

 

[Clean_Journey]

I just checked quickly, and two of the three vendors I've used before are selling it now... let's call them Supplier A and Supplier Q.

Supplier M doesn't seem to have it listed yet...

FYI only, not an endorsement, just a quick check. So, it's out there for research purposes

 

[VeggieBabe]

Can you share a link to the new info?

 

[IF-warrior]

Seriously? What's the point of this post?

 

[Heartxx]

If I remember correctly, there were a couple of Phase 2 trials. Which one are you referring to?

 

[Robin85]

I'd like to see the data you're talking about!

 

[BoldSis1]

Innovent, the company conducting the trials, put out a press release in late July announcing their 2nd phase three trial of Maz in patients with type 2 diabetes and their plans to apply for a new drug application in China. The results look promising.

 

[BoutiqueCompounding]

Just located this concerning Mazdutide:

https://www.nature.com/articles/s41467-023-43761-9

There's a lot of chatter happening about this peptide now.

Given the partnership between Eli Lilly and China on this project…I would anticipate a conflict of interest on both sides down the road.

 

[WildLife]

This drug looks pretty interesting. It is a dual agonist but works on glucagon/glp instead of gip/glp...

 

[IF-warrior]

Mazdutide is like oxyntomodulin (OXM), a natural hormone in our bodies, but it's been tweaked to last much longer. This article mentions:

Oxyntomodulin (OXM) is a dual agonist that boosts energy and curbs appetite, which leads to losing weight. Since OXM doesn't last long, they've been working on longer-lasting versions like cotadutide and mazdutide.

For the real scoop, check out what the drug companies tell their investors, not just what they tell us.

https://img.innoventbio.com/Innoven..._of_Mazdutide_IBI362_2024_ADA_20240624_vf.pdf

 

[Clean_Journey]

That report is really good!

 

[VeggieBabe]

I'm impressed by the effects on liver fat, along with similar weight loss compared to Tirzepatide AND fewer serious side effects. I'm curious how it stacks up against Reta.

 

[IF-warrior]

The link above doesn't seem to be working; try this one:

https://img.innoventbio.com/Innoven..._of_Mazdutide_IBI362_2024_ADA_20240624_vf.pdf

Very fascinating; I'm wondering how it works without the GIP agonism like Reta.

 

[Heartxx]

I tried a few doses of this and it really messed with my heart. I'm going to hold off for a bit. Sema is working well right now, and I feel calm, not all revved up.

 

[IF-warrior]

That's probably the glucagon doing its thing. Reta doesn't do that to me. I take magnesium every night, which helps my heart a lot – I don't need blood pressure meds anymore. I also have benign PVCs, and I haven't had any heart flutters on Reta.

 

[VeggieBabe]

It's wild how expensive these drugs are. I saw an article saying the active ingredient in Ozempic only costs about $5 to manufacture. I understand there's R&D and all that, but the profit margins are insane.

 

[BoldSis1]

I've noticed a change in my cravings since starting GLP-1s. I used to binge on cheap candy, but now if I want something sweet, I want the good stuff. Like, a really nice dark chocolate. Anyone else?

 

[Clean_Journey]

I agree with BoldSis1. I'm eating way less junk food, but when I do want something, it's gotta be high-quality chocolate. I got a Lindt bar the other day!

 

[BoutiqueCompounding]

That would be the glucagon action at play obviously.

That's an interesting point. I hadn't thought about the glucagon aspect being the main driver of the heart issues. I'll have to look into that further.