Mice getting all the good stuff?

Stevie_1986

Stevie_1986

Member
Hey all,

I saw this article about how researchers managed to increase the lifespan of older male mice by around 70% using a specific drug combination.

Apparently, combining oxytocin and an Alk5 inhibitor had a revitalizing effect on very old male mice, improving both their lifespan and physical strength. However, the female mice only showed short-term improvements, highlighting a significant difference in how aging affects males and females. The therapy seemed to restore more youthful protein patterns, too.

www.sciencedaily.com

I thought this could be interesting for some of you. Even though it's just mice, a 70% increase is pretty impressive!
 
I'm definitely guilty of immediately searching for Alk5 inhibitors before even reading the entire article. Anyone else?
 
Guilty as charged! I skimmed it a while back and did the same thing. From what I could find, there aren't any readily available, naturally occurring ALK5 inhibitors that are specific and safe for consumption, at least not with sufficient testing in rodents, let alone humans.

I'm more intrigued by glycine, NAC, and ergothionine though.
 
Between my ruined knees, shot hips, and arthritic back, I'm not sure I'd even want a longer life.

I'm only half kidding. If someone offered me healthy joints in exchange for a shorter life, I would have to consider it.
 
A lot of these peptides seem to work way better in mice. AOD is a prime example. Mice have a ton of beta-3 receptors, which humans don't have nearly as many of.
 
It really does seem like rodent medicine is way ahead of human medicine, judging by all these research studies.
 
Exactly! What works in rodents isn't always the same in humans. Lots of products with promising early studies wind up failing because they don't affect humans the same way. Any peptides I take need to have solid human trials showing promise.
 
If the price is right and the lab has barely pronounceable name, who needs human trials? Kidding! 😆
 
I wanted to say how much I value what you bring to the discussions here—thanks!

I'm wary of AI LLMs pulling weird, unreliable info, but this seems useful for assessing the odds of human effectiveness. Does it provide its sources?

I'm curious about Gemini's take on a synthetic tetrapeptide—Lys‑Glu‑Asp‑Pro (KEDP). How would your question be phrased?
 
Hey just curious, has anyone tried semax for a mood boost? I've been experimenting with injectable semax around 350mcg, on/off, for a couple weeks, and I think it helps a lot with mental well-being. It's hard to describe, but it sort of feels like Adderall without the crazy euphoria or side effects, but with a decent mood uplift.

Just a heads up:
a) Smaller doses seem best; higher doses just cause more anxiety. 250-350mcg seems to be the sweet spot for me.
b) AM dosing is best.
 
Has anyone experienced bad acne from taking sermorelin? I started about a month ago and my acne has been awful the last couple weeks. My doc was unhelpful. I'm thinking of stopping it completely. Ugh.
 
Stacy05 said:
Has anyone experienced bad acne from taking sermorelin? I started about a month ago and my acne has been awful the last couple weeks. My doc was unhelpful. I'm thinking of stopping it completely. Ugh.
Click to expand...

Sermorelin can raise IGF-1 levels, which may worsen acne.
 
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