Mounjaro (Tirzepatide) Experiences?

Eddie1987

Eddie1987

Well-known member
Hey all. I'm a 56 year old woman and have had Type 1 diabetes for 53 years. Also on TRT for 5 years--it's helped a lot with my glucose control + libido. Found a decent TRT doc about 3 years ago. I'm in Idaho, so choices are limited. He switched me to a new physician in his practice last summer (2021). My T levels were pretty good, between 550 and 700 (tested every 3 months).

I was taking:
Testosterone cypionate 20 mg every 3.5 days (200mg/ml), so 80mg weekly.
Anastrozole 0.5mg every 3.5 days

My E2 was around 26-36 pg/ml. Without the anastrozole, it'd be 70+. Test was ultrasensitive.
SHBG 40 nmol/L
Free T 60 pg/ml
Bioavailable T 105 ng/dl

I felt OK. Sex drive was okay, morning wood was rare.

New doc wanted to see my numbers higher, so doubled my T dose to 160mg a week, subq, split every 3.5 days. I kept the anastrozole the same. I did feel better, and morning wood came back.

Last September, I got terrible pain in my left foot—plantar fasciitis, I think. Stretching didn't help much; walking helped a bit, and ibuprofen helped some. I wondered if I could stop the anastrozole and see if my E2 would stay down. I stopped it about 4 weeks before my quarterly testing.

The foot pain went away. I didn't connect it to the anastrozole at the time.

When I had my bloodwork done, my E2 was 74, so I started back on anastrozole, and the foot pain came back immediately. I thought it might be a coincidence, so I stopped the anastrozole again, and the pain subsided within 3 days. After a couple of weeks, I restarted the anastrozole to be sure. The pain returned within 60 hours.

Also, the foot pain started 2 weeks after my second COVID shot. I think the vaccine triggered the anastrozole side effect.

My TRT doc agreed the anastrozole was causing the tendon issue, and he put me on 60mg a day of Raloxifene. I've been on it for 3 months, and my E2 is still 70. No change. He wants to double the dose to 120mg a day. From what I've read, Raloxifene is mainly for gynecomastia, not for lowering E2.

Any feedback on using raloxifene for high E2?

My erections aren't as good. Is it the high E2 or the Raloxifene?

Also, what's a good alternative to anastrozole as an AI?

Thanks!
 
My E2 has been around 75-90 with zero bad effects. Anastrazole blocks aromatase all over, but your body may need different amounts of aromatization for your bones and brain.

Have you thought about lowering the anastrozole down to maybe 0.250 or even 0.125?
 
I've considered a lower dose. I really want to know if the raloxifene will even work. I def feel better when my E2 is around 40.
 
Raloxifene is a SERM—a selective estrogen receptor modulator. These drugs block estrogen's access to certain receptors, selectively changing estrogenic activity. They don't lower estrogen levels. An aromatase inhibitor, such as anastrozole, blocks estradiol formation, lowering levels and reducing all estrogenic activity. SERMs can be tricky because their exact effects are sometimes hard to predict. Raloxifene is anti-estrogenic in the breasts, estrogenic in the bones and liver, and has mixed activity in the brain.

You need to find out if you're reacting to the anastrozole itself or the lower estrogen levels. There are other AIs you could try if the issue is the specific drug. For example, exemestane or letrozole.

Personally, I wouldn't want to stay on such a high T dose for long. Maybe try a lower dose to see if you can get the benefits with less testosterone.
 
I'm not sure, but my E2 seems to go up and down with my CBC values. I might just test my E2 out of curiosity.
 
I've been on Mounjaro (tirzepatide) for about six months now, and it's been a game changer for my diabetes. It's a dual GIP and GLP-1 receptor agonist, which I understand boosts insulin release and reduces glucagon. I've dropped about 30 pounds, and my blood sugar is so much more stable.
 
work-in-progress said:
I'm dealing with some nasty constipation since starting Mounjaro. Any tips? I've heard it's a common side effect.
Click to expand...

Oh yeah, the constipation is a real thing! For me, psyllium husk has helped a lot. Also, make sure you're drinking tons of water. Some people swear by Milk of Magnesia, but I haven't tried that personally.
 
Just a heads up, tirzepatide, like other GLP-1 agonists, can sometimes affect how other medications are absorbed. It slows down gastric emptying, so it's worth checking with your doctor or pharmacist if you're taking anything else, especially oral meds.
 
You must log in or register to reply here.
Back
Top