Mounjaro to peps... what's next?

Hong Kong Yanpep International
E_Grace_H

E_Grace_H

Well-known member
Hi all,

I'm looking for advice on moving from a GLP-1 to peptides. I was on Mounjaro since last spring, went from 230 lbs to about 175 lbs. I never went above 7.5mg dose and it worked great. I went from roughly 34% bodyfat to around 18%, but I also lost muscle mass, and seem a bit deflated. I lift weights regularly and have a decent muscle foundation, but still... My main concern is the extra skin around my midsection. It isn't excessive, but it prevents me from looking as toned as I feel.

I could try to diet more, but I believe I need to focus on rebuilding muscle, tightening the skin, and promoting recovery. I also have some previous cartilage damage in my knee from an old sports injury, so I’d like to help with that too.

I'm thinking of trying a peptide combo, like Tesamorelin and Ipamorelin, maybe also BPC-157 for tissue and joint healing, plus GHK-Cu for skin elasticity. I'm not looking for more fat loss, but to recomp, build muscle, improve skin, and help my knee.

Has anyone tried something similar after stopping Mounjaro? Any feedback on dosages, scheduling, or suggestions on what to add or remove would be appreciated. I work out 4-5 times a week and eat about 2000 calories with high protein intake.

Thanks!
 
This isn't a recommendation, but consider this hypothetical stack: Enclomiphene, Tesamorelin, and Ipamorelin.

This combo could optimize testosterone (via Enclomiphene, which may maintain fertility) as well as Growth Hormone/IGF-1 (via Tesamorelin/Ipamorelin for better body composition and recovery).

However, this carries increased cardiovascular and metabolic stress (like higher blood glucose), and requires careful medical monitoring due to potential long-term effects of simultaneously stimulating these endocrine systems. Frequent bloodwork is recommended to monitor:

* Testosterone (Total & Free)
* Luteinizing Hormone (LH) and FSH
* Estradiol (E2)
* IGF-1 (to track GH axis activation)
* Comprehensive Metabolic Panel (CMP) to monitor glucose/insulin.

Copper peptide ~2mg daily for skin tightening has mixed reviews, so see how it works. BPC-157 daily and TB500 weekly seems like a usual protocol for tissue repair/recovery. NAD+ and KPV are also possibilities for lowering inflammation and boosting energy. But these have very little human studies backing them up. So, proceed with caution.
 
Thanks for the detailed advice. This is interesting. I’ve looked into Enclomiphene before, but never considered it in this type of stack.

Doesn’t Enclo have some potential side effects? Like increased estrogen, mood changes, headaches, or blurred vision?

I’ve seen conflicting information; some say it’s clean, while others complain about estrogen issues or feeling unwell after a few weeks.

I'm curious about your experience or opinion on this.
 
I have no firsthand experience with this combo or the individual peptides. Just from reading online.
 
My understanding is that genuine enclomiphene is less likely to cause visual disturbances. Clomiphene (Clomid) has a worse side effect profile. Enclomiphene is one of the two versions of clomiphene (the other being zuclomiphene, which might be estrogenic and responsible for the nasty sides), and it's often harder to acquire. Many shady vendors sell clomiphene but label it as enclomiphene.
 
Hey E_Grace_H, congrats on the weight loss! I lost like 50 pounds in the last year... mostly around my belly. Now I got this weird skin fold on my inner thigh when I sit down. It's kinda raw and sore, like a pressure sore or something. Anyone else get anything like that?
 
CalorieMom41 said:
Hey E_Grace_H, congrats on the weight loss! I lost like 50 pounds in the last year... mostly around my belly. Now I got this weird skin fold on my inner thigh when I sit down. It's kinda raw and sore, like a pressure sore or something. Anyone else get anything like that?
Click to expand...

Hello! I'm a registered nurse.
For the sore area, go to your local pharmacy and purchase silicone foam dressings. Ensure the area is clean and dry before applying. Change as often as needed to keep it clean/dry. See your primary care physician if it worsens. Frequent position changes (standing/shifting) are essential.
 
Trail_05 said:
Hello! I'm a registered nurse.
For the sore area, go to your local pharmacy and purchase silicone foam dressings. Ensure the area is clean and dry before applying. Change as often as needed to keep it clean/dry. See your primary care physician if it worsens. Frequent position changes (standing/shifting) are essential.
Click to expand...

Thanks! I'll try that. Standing more is tough at my desk job but I'll try to get up and walk around every hour.
 
Thanks Trail_05 for the advice to CalorieMom41 ! I'm going to grab some of those dressings just in case... maybe good to have on hand. I'm more worried about "Ozempic face" at this point haha...

Anyone else get told they look older after losing weight? A doctor actually wrote in my chart that I appear older than I am! Rude, but kinda true.
 
E_Grace_H said:
Thanks Trail_05 for the advice to CalorieMom41 ! I'm going to grab some of those dressings just in case... maybe good to have on hand. I'm more worried about "Ozempic face" at this point haha...

Anyone else get told they look older after losing weight? A doctor actually wrote in my chart that I appear older than I am! Rude, but kinda true.
Click to expand...

Wow, that's... something. It's common for doctors to note a patient's apparent age relative to their actual age in the review of systems. It's often insurance-driven, so don't take it too personally.
 
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