Myostatin blockers & GLP-1s?

FunkyBetter

FunkyBetter

Well-known member
I'm interested in myostatin research, specifically ActRIIB ligands, however, I can't find too much discussion about it here. It seems like most people just stick to creatine or Beta-Alanine. I'm surprised there aren't more conversations, especially since there are several Phase 2 clinical trials wrapping up for different medications. I would assume people here would be interested in this? I'm curious if anyone has come across a reliable source.
 
Aren't most of those myostatin inhibitors monoclonal antibodies? Those are way harder to synthesize than basic peptides. I haven't seen any openly available from research chemical suppliers, only from pharmaceutical companies. I've seen myostatin *inhibitors* for sale too, which seems counterintuitive since that would *increase* muscle growth, not decrease it. What's the market for that?
 
I think you're misunderstanding. ACE-031 does the *opposite* of inhibiting muscle growth. That's why some bodybuilders will stack it with GLP-1 receptor agonists. It's meant to help you gain muscle without the more severe side effects from anabolics or SARMs.

Yes, I know Garetosmab and Trevogrumab are pharmaceutical-grade and won't be available for a few years, if ever. I'm specifically asking about ACE-031, which I think is out there but expensive. Wondering if anyone's found a good source?
 
Those monoclonal antibodies have to be produced in genetically modified hamster cells, which makes it way more complicated and expensive. It probably explains why more research is being done on monoclonal antibodies rather than peptides. ACE-031 had some pretty serious issues during its trials, so it was discontinued. It wasn't safe, and caused significant off-target effects. I read somewhere:

"Adverse events outside of muscle tissue contributed to the decision to halt the trial...stopped after the second dosage due to potential safety concerns of nosebleeds..."

It was found to inhibit BMP9 and BMP10, and caused a large decrease in follicle stimulating hormone
 
Thanks for the details on ACE-031. I appreciate the explanation on why it isn't more widely available. I'm here to learn, and that was helpful!
 
Follistatin seems kinda similar. I haven't seen much about it though, and if it REALLY worked, the guys online would be all over it. I'm a bit skeptical.
 
What do you think about HMB? Some people swear by it for muscle retention, but others say it's a waste of money.
 
Myostatin inhibitors sound amazing in theory. We've all seen the photos of the buff cows and the toddler that could lift a ton. ACE-031 isn't the only one that had issues in early human trials after promising animal studies. As far as I am aware, there are no available myostatin blockers with human data showing it is both effective and safe. Big Pharma is still trying to come up with new versions, so we might see some in the future. However, they might be monoclonal antibodies instead of peptides. Do your research before trying them because a lot have had unexpected side effects.

I am not a pharmacology expert. I just have a degree in a related field and spend a lot of time looking at the chemicals for sale online.
 
I've been taking 3g orally every day since I started Reta. I'm down about 15 pounds and the scale says my lean mass hasn't changed. I know scales aren't perfect, but it should at least be a good indicator of trends.
 
My husband is considering starting a low dose of Reta after the holidays, but he's concerned about losing muscle. I've been doing some research for him. Was thinking 3g/day sounds right. Thanks!
 
From what I've read, you lose about the same percentage of lean mass on GLP-1's as you would with any weight loss method. Focus on traditional muscle-sparing interventions: resistance training, high protein (about 1.5-2g/kg of bodyweight, split into 3-4 meals), and sleep. Supplements like HMB, Creatine, BCAAs (especially Leucine), Cal/Mag/Zinc/D/K2, and Omega-3 FA can also help, but they aren't as effective as diet, sleep, and training. GH secretagogues are another option, but require even more research.

I'm doing resistance training, high protein, creatine, collagen, HMB, and omega-3's. So far, things are going well.
 
This podcast with Dr. Seeds touches on the idea that GLP-1's work on the atrophy gene and help with bone density during weight loss https://youtu.be/xI6Rs-LTSKc?si=WYo95lk9CAuSQ0XI. He also thinks it's wrong when people say you'll regain all the weight back if you come off GLP-1's. It's about using the time on the medication to implement long-term lifestyle changes like diet and exercise.
 
I'm doing 3g per day of free acid HMB. I'm down about 20 lbs in 3 months, and my body scans show my lean body mass is staying put. Still making small strength gains, but not like I used to. I've heard that 5-amino-1mq is supposed to help preserve muscle too.

I have always been drug-free, but I am considering a low dose of Ostarine along with Reta.
 
I studied pre-med and robotics with a focus on stats and data, but I still feel like I barely know anything compared to people who have advanced degrees. It's impossible to learn everything, even if you work in the field. Sigh
 
Thanks for the link, I'll check it out.

I agree that regain is not inevitable. There's a good amount of evidence that Reta actually helps repair the issues, not just curb appetite.

I stopped Sema and Reta long enough to get my energy back, I've been doing more cardio, and I've lost a few pounds. I'm back to drinking a ton of water every day. I'll post more when I start taking it again. It's just one data point, but better than nothing.
 
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