PT-141 Timing: Night vs Day?

TBH

TBH

Active member
Wondering if anyone else has played around with injection timing for PT-141. This stuff is amazing, but the results are all over the place for me.

Last time, I pinned it around 10 PM before bed. Woke up at like 3 AM rock hard. Almost got worried about priapism, but managed to deal with it. Had a slight… awareness… down there most of the next day lol. Messed with my sleep, but felt like I was 20 again.

Then, a week later, same batch, I tried injecting around 11 in the morning, and it barely did anything. A few random tingles during the day, but nothing like the night shot.

Thinking maybe sleeping after the injection makes it work better? Anyone else notice this? Maybe experimenting with naps after, or even injecting in the middle of the night is the play.
 
From what I recall reading, 141 can be hit or miss each time. I don't think you're supposed to use it too often either. I think it was best timed around eating carbs, but I could be mixing it up with GHRP2/6. I had a few times where I was super focused on sex on 141, but most of the time, nothing happened. I think I got up to 2mg at the end.
 
That's why I made this thread. My inconsistent results usually happen during the day or maybe 4 hours before sexy time. But the shots before bed, those have been awesome, but a disruptive sleep and a sleeping partner aren't ideal when you wake up super hard.

And I agree, I use it sparingly, maybe twice a month. It seems like its effectiveness goes down when you use it all the time. I started at a low dose of .5 mg and slowly went up. I didn't see benefits till I got to 1.5 mg. Now I take 1.75 mg and haven't tried any higher.

Thinking about trying 2 mg during the day to see if that changes anything. I guess I'm fortunate that I haven't had any nausea or flushing at any dose.
 
Vince, I'll try to explain why my post about Melanotan II is relevant. Both Melanotan II and PT-141 are melanocortin agonists. They both indirectly act on dopamine. PT-141 was made from Melanotan II to try to isolate the effects on erections and libido. It's considered more potent and selective for that. But, experiences vary. So, PT-141 doesn't affect the MC1 receptors as much, which causes the tanning effect of Melanotan II. However, they both cause erections the same way, through neurological modulation of MC receptors.

The observation that these work best for morning wood isn't just in this thread. Others have the same experience. I think it's because erections are neurologically caused by parasympathetic nerves. Since these work on a neurological level, they provide the parasympathetic boost needed to cause an erection when we are already in a parasympathetic state (rest or sleep). The effect seems to take about 6-7 hours, which lines up with deep sleep cycles and the natural timing of morning wood.

So, that's why I posted. I don't want any credit, just want to avoid ignorant comments. I hope this clarifies things for anyone who's quick to criticize.
 
Thanks, JPB, for the info. Some of that was over my head, but I still appreciate you trying to explain it.

So, do you think sleeping after dosing increases the effect? Is it like "mimicking" morning wood, so that's why it seems less effective during the day?

I've never used Trimix, but the 10 PM shot and the 2 AM raging erection felt like what I'd expect from Trimix. I was actually worried about priapism lol.
 
Yes, I wouldn't say it mimics morning wood but helps create the right neurological circadian effects to help it happen. Just a more robust, youthful pattern. This would most likely be during your normal (overnight) sleeping patterns, but could happen with a daytime nap, too, I guess. Really anything that induces a stronger parasympathetic shift will make erections more likely. But there seems to be a pronounced sweet spot with these peptides and morning wood. I think Melanotan II is a more cost-effective option, and I use it nightly. But you will get the hyperpigmentation and tanning effects, too.
 
I took PT 141 for the first time last week, 1mg at 7:30 AM, walked the dogs, showered, and went to the gym. Everything I read said it would take about 3-4 hours to work. At the gym, about 2 1/2 hours after the shot, I started getting super hard and had to leave before finishing my workout. Got home, my wife was still asleep, so I made breakfast but couldn’t stop thinking about sex was driving me nuts. Also, the AC wasn’t working, and it was super hot. She said it was too hot for sex. I had a hard one for around eight hours and random ones on and off all night. Flushing for the first hour and a headache after maybe four hours. It was crazy and wild, and I will keep doing it as long as the headaches aren’t too bad. Definitely getting the AC fixed lol
 
Caffeine_Queen said:
I've been reading about Sermorelin online lately. It seems interesting. Has anyone tried it solo?
Click to expand...

I have. However, from my research, it is more effective when stacked with a GHRP like GHRP-2 or GHRP-6. The GHRP sort of turns on the pituitary while the Sermorelin tells it how much to produce. It's all based on your goals and current levels, though.
 
I was under the impression that Sermorelin was useless by itself? A nearby clinic offers Sermorelin with GHRP-2 but it is really expensive. Would GHRP-2 + CJC-1295 be the same? That combination is much cheaper.
 
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