Restarting at the Lowest Dose?!

[slim_sketcher]

The pharmacokinetic model versus symptom-based titration question has a practical answer: most people end up going by symptoms because theoretical models don't account for individual variability well enough to be prescriptive. How you feel at each dose level is the real data.

 

[rusty_climber]

A single skipped dose typically does not require restarting at the bottom - the guidance to restart at the same dose after a single miss is well-documented. The insurance requirement to restart at the lowest dose is a coverage rule rather than a medical one.